醒脑静注射液对急性脑梗死患者血清VEGF表达的影响

Effects of Xingnaojing Injection on the Expression of Vascular endothelial Growth Factor in Patients with Acute Cerebral Infarction

目的:观察醒脑静注射液对急性脑梗死患者血清血管内皮生长因子(VEGF)表达的影响。方法:65例急性脑梗死患者随机分为醒脑静注射液治疗组33例和对照组32例,另设立正常对照组60例。两组急性脑梗死患者均给予常规抗血小板、他汀类药物治疗,治疗组在此基础上加用醒脑静注射液20mL加入生理盐水250mL中静滴,1天1次,14天为1个疗程。采用双抗体夹心酶联免疫吸附法(ELISA)动态测定两组患者发病第1、3、7、14天时血清VEGF浓度。同时记录入院时和治疗14天的脑梗死灶体积,并进行神经功能缺损评分(NIHSS)。结果:与正常对照组比较,65例患者中风后1、3、7、14天各时间点的血清VEGF浓度均明显增高,差异有统计学意义(P<0.05)。中风后第3、7、14天治疗组血清VEGF浓度明显高于对照组,差异有统计学意义(P<0.05);治疗14天后,治疗组平均脑梗死灶体积小于对照组,差异有统计学意义(P<0.05),14天后治疗组NIHSS评分虽优于对照组,但两组差异无统计学意义(P>0.05)。结论:醒脑静注射液能促进急性脑梗死后血清VEGF的表达,参与新生血管形成,提高临床疗效。

Objective： To explore the effects of Xingnaojing injection on the expression of vascular endothelial growth factor （VEGF） in patients with acute cerebral infarction （ACI）. Methods： Sixty-five patients with ACI were randomly divided into Xingnaojing treatment group （experimental group, n=33） and routine treatment group（n= 32）. Both groups were treated with anti-platelet aggregation and stating, and patients in the experimental group were given additional Xingnaojing injection （20mL/250mL saline, vd, qd） for 14 days. Serum concentrations of VEGF were measured by double antibody sandwich ELISA on day 1,3,7 and 14 after the onset of stroke. Vol- umes of infarction and scores of national institutes of health stroke scale（NIHSS）were recorded on admission and on day 14. Other 60 healthy individuals served as blank controls. Results： Compared with the blank control group, the serum concentrations of VEGF in patients with ACI on day 1,3,7 and 14 were obviously increased （1~〈0.05）. The serum concentrations of VEGF in the experimental group on day 3,7 and 14 were significantly higher than those of routine treatment group （P〈0.05）. After 14-day treatment, the experimental group had less volume of infarction than routine treatment group did（P〈0.05） and had better NIHSS scores but no statistical dif- ference（P〉0.05）. Conclusion： Xingnaojing injection can promote the production of VEGF and participate in angio- genesis after ACI,which is expected to improve the therapeutic effect.