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强直性脊柱炎的易感基因研究 被引量：1

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摘要 强直性脊柱炎（ankylosing spondylitis，AS）是一种遗传相关性显著的血清阴性脊柱关节病（seronegative spondyloarthropathies，SpAs），主要累及骶髂关节和中轴骨骼，并常发生椎间盘纤维环及附近韧带的钙化和骨性强直。已知AS有显著的人种和地理差异，且具有显著的家族遗传倾向。双胞胎研究估计，其90％以上的易感性由遗传因素决定。AS临床表现的遗传现象也十分显著，广泛采用Bath强直性脊柱炎病情活动指数调查表（BASDAI）和Bath强直性脊柱炎功能指数（BASFI）对疾病活动评估的调查结果显示分别为51％和76％。
作者 陈彬 徐卫东
机构地区 第二军医大学附属长海医院骨科(关节外科)
出处 《中华关节外科杂志（电子版）》 CAS 2012年第5期77-79,共3页 Chinese Journal of Joint Surgery(Electronic Edition)
基金 上海市科委基础重点项目(10JC1417900)
关键词 Bath强直性脊柱炎 易感基因 血清阴性脊柱关节病 椎间盘纤维环 病情活动指数 遗传相关性 骶髂关节 骨性强直
分类号 R593.23 [医药卫生—内科学]
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参考文献25

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  • 2Thomas GP, Brown MA. Genetics and genomics of ankylosingspondylitis. Immunol Rev, 2010, 233 : 162 - 180.
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  • 5Zhang L,Liu JL, Zhang YJ, et al. Association between HLA-B *27 polymorphisms and ankylosing spondylitis in Han populations :a meta-analysis. Clin Exp Rheumatol, 2011,29: 285 -292.
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同被引文献27

  • 1Smith JA, Mrker Hermann E, Colbert RA. Pathogenesis of ankylosing spondylitis: current concepts. Best Pract Res Clin Rheumatol. 2006;20(3):571-591.
  • 2Khan MA, Mathieu A, Sorrentino R, et al.The pathoge netic role of HLAB-27 and its subtypes. Autoimmun Rev. 2007;6(3): 183-189.
  • 3Robinson WP, van der Linden SM, Khan MA, et al. HLA-Bw60 increases susceptibility to ankylosing spo-ndylitis in HLA-B27 patients. Arthtis Rheum. 1989;32(9):1135-1141.
  • 4Wei JC, Tsai WC, Lin HS, et al. HLA-B60 and B61 are strongly associated with ankylosing spondylitis in HLA-B27-negative Taiwan Chinese patients. Rheumatology (Oxford). 2004;43(7):839-842.
  • 5Vargas-Alarcon G, Londono JD, Hernandez-Pacheco G, et al. Effect of HLA-B and HLA-DR genes on susceptibility to and severity of spondyloarthropa thies in Mexi can patients. Ann Rheum Dis. 2002;61(8): 714-717.
  • 6Braun J, van der Heijde D. Novel approaches in the treatment of an kylosing spondylitis and other spondyloarthritides. Exp Opin Invest Drugs. 2003; 12(7): 1097-1109.
  • 7Brown MA, Kennedy LG, Darke C, et al. The effect of HLA-DR genes on susceptibility to and severity of ankylosing spondylitis. Arthritis Rheum. 1998;41(3): 460-465.
  • 8Said-Nahal R, Miceli-Richard C, Gautreau C, et al. The role of HLA genes in familial spondyloarthropathy: a comprehensive study of 70 multiplex families. Ann Rheum Dis. 2002;61 (3):201-206.
  • 9Inanc B, Elcin AE, Elcin YM, et al. Osteogenic induction of human periodontal ligament fibroblasts under two-and three-dimensional cult-ure conditions. Tissue Eng. 2006;12(2):257-266.
  • 10Maksymowych WP, Suarez-Almazor M, Chou CT, et al. Poly-morphism in the LMP2 gene influences susceptibility to extraspinal disease in HLA-B27 positive individuals with ankylosing spondylitis. Ann Rheum DR. 1995;54(4):321-324.

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中华关节外科杂志（电子版）
2012年 第5期

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