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新型1-对三氟甲基苯基-β-咔啉-3-羰基双酰肼的合成及其抗菌活性 被引量：3

Synthesis and Antibacterial Activities of Novel 1-Trifluoromethyl-phenyl-β-carboline-3-carbonyl-diacylhydrazine
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摘要 以L-色氨酸和对三氟甲基苯甲醛为原料,经Pictet-Spengler环合、酯化、氧化、肼解、酰化五步反应合成了四个新型的1-对三氟甲基苯基-β-咔啉-3-羰基双酰肼(5a～5d),其结构经1H NMR,IR,MS和元素分析表征。初步的抗菌活性测试结果表明,5b～5d对水稻纹枯菌有一定的抗菌活性。 Four novel 1-trifluoromethyl-phenyl-β-carboline-3-carbonyl-diacylhydrazine（5a～5d） were synthesized from L-tryptophan and trifluoromethyl-benzaldehyde by a five-step reactions of Pictet-Spengler condensation,esterification,oxidation,N-alkylation and acylation.The structures were characterized by 1H NMR,IR,MS and elemental analysis.The preliminary antibacterial tests showed that 5b～5d exhibited certain antifungal activities against Rhizoctonia solani.
作者 蔡瑛 黄剑锋 张美丹 曾勇 张耀谋
机构地区 华南农业大学理学院 华南农业大学资源环境学院
出处 《合成化学》 CAS CSCD 北大核心 2012年第6期736-739,共4页 Chinese Journal of Synthetic Chemistry
关键词 L-色氨酸 双酰肼 合成 抗菌活性 L-tryptophan β-carboline-diacylhydrazine synthesis antibacterial activity
分类号 O623.75 [理学—有机化学] O625.63 [理学—有机化学]
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合成化学
2012年 第6期

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