RANK、RANKL与人工关节磨损颗粒诱导骨溶解被引量：5

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摘要人工关节磨损颗粒诱导的骨溶解是人工关节置换术后无菌性松动的最主要原因。人工关节各个部件相互摩擦产生的磨损颗粒经体内巨噬细胞反复吞噬、刺激产生多种细胞因子和炎症介质。磨损颗粒与巨噬细胞相互作用产生的促炎症反应使破骨细胞过度生成和激活,人工关节周围正常骨质被吸收破坏,最终形成骨溶解和无菌性松动。研究证实,细胞核因子κB活化因子受体(RANK)及其配体(RANKL)在骨溶解中起重要作用。该文就RANK、RANKL结构,生物学功能及其与磨损颗粒诱导骨溶解的关系等近期研究进展作一综述。

作者陈德胜张先龙

机构地区上海交通大学附属第六人民医院骨科

出处《国际骨科学杂志》 2012年第6期398-400,共3页 International Journal of Orthopaedics

关键词细胞核因子κB活化因子受体细胞核因子κB活化因子受体配体无菌性松动磨损颗粒骨溶解

分类号 R318.1 [医药卫生—生物医学工程]

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