survivin在膀胱移行细胞癌中的表达及意义

The expression and significance of survivin in bladder transitional cell carcinoma

目的探讨凋亡抑制基因survivin在膀胱移行细胞癌中的表达及意义。方法膀胱移行细胞癌组87例，20例正常正常膀胱黏膜作为对照，采用免疫组织化学方法检测survivin蛋白表达，然后分析survivin蛋白在膀胱癌组织中的表达情况，以及随着不同临床分期和病理分级表达的变化。结果所有膀胱癌患者平均年龄56．1岁，其中男性患者48例。免疫组织化学分析表明，survivin蛋白表达在细胞的细胞核。膀胱癌组织中survivin表达明显高于正常对照组。随着临床分期的进展，survivin表达上升。结论survivin在膀胱移行细胞癌的生物学行为中起重要作用，survivin与膀胱移行细胞癌的恶性进展有关。

Objectives To investigate the apoptosis gene survivin expression in bladder transitional cell carcinoma and its significance. Methods Bladder Transitional cell carcinoma 87 cases, 20 cases of normal, nor- real bladder mucosa served as controls, using immanohistochemistry to detect expression of survivin protein, and then analysis of survivin protein expression in bladder cancer, as well as the different clinical stage and histological grading expression changes. Results The average age of all patients with bladder cancer is 56.1 years old, 48 cases were male patients. Immunohistochemical analysis of survivin protein expression in the cell nucleus. Survivin expression in bladder cancer tissue was significantly higher than the normal control group. With the progress of clinical stage, sur- vivin expression increased. Conclusions Survivin plays an important role in the biological behavior and malig- nant progression of bladder transitional cell carcinoma.