期刊文献+

SHH信号转导通路参与炎症反应发生机制的研究进展

原文传递
导出
摘要 炎症反应通过细胞因子的作用参与多种疾病的发生和发展,如缺血性疾病、糖尿病等。Hedgehog(HH)信号通路作为与发育相关的重要信号转导途径,近来被报道与保护细胞免受细胞因子相关的细胞毒性作用相关。其中音猬因子(SHH)信号通路研究最多。目前有研究表明SHH信号转导通路可能在炎症反应的发生机制中起关键作用。
出处 《国际泌尿系统杂志》 2012年第6期824-826,共3页 International Journal of Urology and Nephrology
基金 辽宁省医学高峰建设工程重点科研项目(200938) 沈阳市科技攻关计划项目(F11-262-9-06)
关键词 炎症 信号传递
  • 相关文献

参考文献20

  • 1Fitch PM, Howie SE,Wallace WA. Oxidative damage and TGF -P differentially induce lung epithelial cell sonic hedgehog and tena-scin - C expression : implications for the regulation of lung remod-elling in idiopathic interstitial lung disease. Int J Exp Pathol,2011,92(1):8 -17.
  • 2Tzelepi V,Karlou M, Wen S. Expression of hedgehog pathwaycomponents in prostate carcinoma microenvironment : shifting thebalance towards autocrine signalling. Histopathology,2011,58(7):1037-1047.
  • 3Maitah MY, Ali S, Ahmad A, et al. Up - regulation of sonichedgehog contributes to TGF - pi - induced epithelial to mesen-chymal transition in NSCLC cells. PLoS One, 2011, 6(1):el6068..
  • 4Ozturk H, Tuncer MC, Ozturk H ,et al. Nitric oxide regulates ex-pression of sonic hedgehog and hypoxia - inducible factor - 1 alphain an experimental model of kidney ischemia - reperfusion. RenFail,2007,29(3) :249-256.
  • 5Ruo - Lian Dai,Sheng - Yin Zhu,Yuan - Peng Xia, et al. SonicHedgehog Protects Cortical Neurons Against Oxidative Stress. Neu-rochem Res ,2011,36:67 -75.
  • 6Aoto K, Shikata Y, HigasKiyama D ,et al. Fetal ethanol exposureactivates protein kinase A and impairs Shh expression in prechordalmesendoderm cells in the pathogenesis of holoprosencephaly. BirthDefectsResAClinMolTeratol,2008,82(4):224—231.
  • 7Mimeault M, Batra SK. Frequent deregulations in the hedgehog sig-naling network and cross - talks with the epidermal growth factorreceptor pathway involved in cancer progression and targeted thera-pies. Pharmacol Rev,2010,62(3) :497 -524.
  • 8Verzola D, Gan dol fo MT, Ferrari.F, et al. Apoptosis in the kid-neys of patient s with type II diabetic nephropathy. Kidney Interna-tional, 2007,72( 10) : 1 262 -1 272.
  • 9Bar EE, Chaudhry A, Farah MH, et al . Hedgehog signaling pro-motes medulloblastoma survival via Belli. Am J Pathol , 2007,170:347 -355.
  • 10Yamasaki A, Kameda C, Xu R, et al. Nuclear factor kappaB -activated monocytes contribute to pancreatic cancer progressionthrough the production of Shh. Cancer Immunol Immunother,2010,59(5) :675 -686.

相关作者

内容加载中请稍等...

相关机构

内容加载中请稍等...

相关主题

内容加载中请稍等...

浏览历史

内容加载中请稍等...
;
使用帮助 返回顶部