晚期直肠癌术前局部同步放化疗与术后同步放化疗的临床研究

The Clinical Research of Advanced Rectal Cancer Locally Concurrent Chemoradiotherapy in Preoperative and Postoperative

目的:研究术前同步放化疗在晚期直肠癌治疗中的作用。方法:100例晚期直肠癌患者随机分为试验组和对照组,每组各50例。治疗方案分别为术前接受同步放化疗(46GY/23f/5W,PF方案第一周和第五周共2次)和直接手术并在术后视患者具体情况给予同步放化疗(50GY/25f/5W,PF方案每4周一次共4次)。结果:与对照组相比,试验组患者在接受术前同步放化疗后,疾病临床和病理分期降低,手术保肛率高,切除率亦高,而且试验组患者一年生存率升高,局部复发率降低。结论:术前同步放化疗是临床上可行且有效的辅助治疗方案。

Objective ： To investigate the effect of concurrent ehemoradiotherapy in the treatment of advanced coloreetal cancer.Methods ： 100 patients with advanced coloreetal cancer were randomly divided into treatment group and control group, each group 50 patients.Treatment group had received preoperative concurrent chemoradiotherapy （46GY/23f/5W, PF plan in the first and firth weeks）, while the control group received postoperative concurrent chemoradiotherapy （50GY/25f/5W, PF plan once four weeks for four times） if it was necessary.Results ： compared with the controls, preoperative concurrent chemoradiotherapy decreased the clinicopathologic stage and local recurrence rate, while increased the anal-saving rate and resection rate in surgery and the one-year survival rate of patients.Conclusion ： preoperative concurrent chemoradiotherapy is a kind of effective adjuvant therapy in clinic.