摘要
目的:观察坤宁安对围绝经期抑郁模型大鼠行为的影响。方法:鼠龄为12~14个月的雌性SD大鼠,采用孤养结合慢性轻度不可预见性应激造模法造模,对药物影响大鼠行为效果进行观察。结果:抑郁模型组大鼠有体重降低、糖水消耗百分比与蔗糖摄取量显著减少,垂直与水平运动得分减少(P<0.05)。应用坤宁安能够改善上述情况。结论:坤宁安具有抗抑郁作用。
Objective: Observe the effects of Kunningan on perimenopausal depressed rat models' behavior. Methods: Use the female SD rats which the age range from 12 to 14 months. Make the model with the method of the solitary a combining with chronic mild cannot foresight stress, then observe the effects of Kunningan on the behavior of rats. Results: Depressed model rats with weight reduced, sugar water consumption percentage and sugar intake significantly reduced, vertical amt hurizontal mo- tion score reduced ( P 〈 0.05 ) . Kunningan can improve the above situations. Conclusion: Kunningan has antidepressant effects.
出处
《中国药物评价》
2012年第2期118-119,173,共3页
Chinese Journal of Drug Evaluation
基金
黑龙江省中医药科研项目资助课题(项目编号:ZHY10-Z39)