摘要
目的:观察坤宁安对围绝经期抑郁模型大鼠行为的影响。方法:鼠龄为12～14个月的雌性SD大鼠,采用孤养结合慢性轻度不可预见性应激造模法造模,对药物影响大鼠行为效果进行观察。结果:抑郁模型组大鼠有体重降低、糖水消耗百分比与蔗糖摄取量显著减少,垂直与水平运动得分减少(P<0.05)。应用坤宁安能够改善上述情况。结论:坤宁安具有抗抑郁作用。
Objective： Observe the effects of Kunningan on perimenopausal depressed rat models＇ behavior. Methods： Use the female SD rats which the age range from 12 to 14 months. Make the model with the method of the solitary a combining with chronic mild cannot foresight stress, then observe the effects of Kunningan on the behavior of rats. Results： Depressed model rats with weight reduced, sugar water consumption percentage and sugar intake significantly reduced, vertical amt hurizontal mo- tion score reduced （ P 〈 0.05 ） . Kunningan can improve the above situations. Conclusion： Kunningan has antidepressant effects.
出处
《中国药物评价》
2012年第2期118-119,173,共3页
Chinese Journal of Drug Evaluation
基金
黑龙江省中医药科研项目资助课题(项目编号:ZHY10-Z39)
