帕罗西汀联用心理干预治疗抑郁症患者疗效的Meta分析被引量：2

Systematic Review of the Prognosis Effect:Psychological Intervention Combined with Paroxetine Treatment of Depression in Patients with Efficacy and Safety

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摘要目的:评价帕罗西汀联用心理干预治疗抑郁症的疗效及其安全性。方法:通过检索近15年Cochrane Library、Pubmed、Web of Science、Embase、Medline、中国生物医学文献数据库(CBM)、中国学术期刊全文数据库(CNKI)、万方数据库(CECDB)、维普中文科技期刊全文数据库(CQVIP),对纳入研究的方法学进行评价,对文献质量进行严格评价和资料提取,对符合质量标准的RCT用Review manager5.0软件进行Meta分析。结果:5个RCT共413名患者纳入研究,其中治疗组(帕罗西汀联用心理干预治疗)206例,对照组(普通心理治疗、氟西汀、西酞普兰)207例。Meta分析结果表明治疗组患者住院时间、自杀风险、出现强迫症状方面明显低于对照组,具有统计学差异。结论:相比常规治疗,帕罗西汀联用心理干预治疗可显著提升抑郁症患者的疗效。 Objective ： Evaluation of the effects of psyehologieal intervention combined with paroxetine treatment of depression in patients with efficacy and safety. Methods： Searching Cochrane Library,Puhmed,Web of Science ,Embase ,Medline ,CBM ,CNKI, CECDB ,CQVIP, using Review Manager 5.0 Software for Meta-analysis of RCT for analysis. Results： 5 RCT of 413 patients includ- ed in the study, in 206 eases tile treatment group （psychological intervention in conjunction with paroxetine treatment）, 207 eases in the control group （ordinary psychotherapy, fluoxetine, citalopram）. Meta-analysis resuhs showed that the patients treated with duration of hospitalization, risk of suicide, obsessive-compulsive symptoms was significantly lower than the control group, statistical- ly significant. Conclusion： Compared to conventional therapy, psychological intervention plus paroxetine treatment can significantly improve the curative effects in patients with depression.

作者伍勇

机构地区湖北省钟祥市中医院精神科

出处《中国药物评价》 2012年第2期155-159,共5页 Chinese Journal of Drug Evaluation

关键词心理干预帕罗西汀抑郁症 META分析 Psychological intervention Paroxetine Depression Meta-analysis

分类号 R749.4 [医药卫生—神经病学与精神病学]

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