阿托伐他汀治疗原发性高脂血症的临床疗效观察

Observation of Atorvastatin in Treatment of Primary Hyperlipidemia

目的:观察阿托伐他汀治疗原发性高脂血症的疗效和安全性。方法:将82例原发性高脂血症患者随机分为两组,在常规低脂饮食的基础上,治疗组服用阿托伐他汀10mg(40例),对照组服用辛伐他汀20mg(42例),均为每晚1次,疗程12周。评价两组治疗前后血清总胆固醇(TC)、三酰甘油(TG)、低密度脂蛋白胆固醇(LDL-C)和高密度脂蛋白胆固醇(HDL-C)水平变化。结果:服药12周末,与治疗前相比两组TC、TG、LDL-C均显著下降(P<0.01),HDL-C均明显上升(P<0.05),两组间比较差异无统计学意义(P>0.05)。结论:阿托伐他汀可显著降低原发性高脂血症患者TC、TG、LDL-C水平,且剂量低,调脂疗效明确,安全性好。

Objective：Observe the efficacy and safety on atorvastatin regimen continue the treatment of primary hyperlipidemia. Methods： 82 cases of primary hypedipidemia patients were randomly divided into two groups, on the hasis of conventional low-fat diet,the treatment group taking atorvastatin 10rag （40 cases） ,and the control group taking simvastatin 20 mg （42 cases） for 1 time a night. The treatment continued for 12 weeks. Evaluate the two groups on serum total cholesterol （TC） ,Triglyceride （TG） ,low- density lipoprotein cholesterol （LDL-C） and high density lipoprotein cholesterol （HI）L-C） levels before and after treatment. Re- stilts： After 12 weeks, compared with before the treatment, the two groups of the TC, TG and LDL-C decreased significantly （ P 〈 O. 01 ）, HDL-C increased significantly （P 〈 0. 05）, there was no statistically significant difference between the two groups （P 〉 0.05）. Conclusion： Atorvastatin statins significantly lower the TC ,TG and LDL-C levels in patients with primary hyperiipidemia.