胎盘多肽辅助治疗带状疱疹的疗效观察

Clinical Observation of Adjuvant Treatment with Placenta Polypeptide for Herpes Zoster

目的:观察胎盘多肽辅助治疗带状疱疹的疗效,为临床治疗提供新的手段。方法:80例带状疱疹住院患者随机分为治疗组与对照组,每组40例。对照组予以口服泛昔洛韦,静脉输注利巴韦林,口服洛索洛芬止痛,TDP照射理疗;治疗组在对照组治疗基础上静脉滴注胎盘多肽4mL,每天1次。2组治疗疗程均为15d。记录2组患者的止痛时间、止疱时间、结痂时间及痊愈时间,记录治疗后7、15、30d的疼痛程度视觉模拟评分(VAS)。结果:治疗组与对照组的总有效率分别为95.0%、77.5%(P<0.05);治疗组止痛时间、止疱时间、结痂时间及痊愈时间分别为(7.325±1.59)、(3.5±1.03)、(5.75±1.55)、(11.75±1.75)d,对照组分别为(11.175±2.45)、(5.5±1.03)、(7.87±1.50)、(15.27±1.71)d,差异均有统计学意义(P<0.01);治疗组治疗后7、15、30d的VAS分别为(5.25±0.90)、(1.00±1.15)、(0.23±0.53),对照组分别为(6.55±0.96)、(3.28±1.30)、(0.75±1.15),差异均有统计学意义(P<0.01)。结论:胎盘多肽辅助治疗带状疱疹能显著缩短疗程,减轻神经疼痛,缩短止痛、止疱及结痂时间。

OBJECTIVE： To observe clinical efficacy of adjuvant treatment with placenta polypeptide for herpes zoster, and to provide new therapeutic approaches. METHODS： 80 patients with herpes zoster were randomly divided into treatment group and control group with 40 patients in each group. Control group was given oral dose of famciclovir, intravenous administration of ribavirin, oral administration of loxoprofen for analgesis and TDP physiotherapy. Treatment group was given intravenous drip of placenta polypeptide 4 mL once a day on the basis of treatment in control group. The course of treatment lasted for 15 d. The time of pain relief, stopping vesiculation and incrustation and cure duration were recorded, and VAS were recorded 7 d, 15 d and 30 d after treatment. RESULTS： The total effective rate of treatment group was 95.0% and that of control group was 77.5% （P0.05）. The time of pain relief, stopping vesiculation and incrustation and cure duration were （7.325±1.59）d,（3.5±1.03）d,（5.75±1.55）d and （11.75±1.75）d in treatment group and （11.175±2.45）d,（5.5±1.03 ）d,（7.87±1.50）d and （15.27±1.71）d in control group. There was statistical significance （P0.01）. The VAS of treatment group was （5.25±0.90）, （1.00±1.15）, （0.23±0.53） after 7 d, 15 d, 30 d of treatment, and that of control group was （6.55±0.96）, （3.28±1.30）,（0.75±1.15）. There was statistical significance （P0.01）. CONCLUSION： The adjuvant treatment with placenta polypeptide for herpes zoster can significantly shorten treatment course, reduce nerve pain, reduce the time of pain relief, stopping vesiculation and incrustation.