我院482例药品不良反应报告分析

Analysis of 482 Cases of Adverse Drug Reaction Reports in Our Hospital

目的:了解我院药品不良反应(ADR)发生的特点及一般规律,促进临床合理用药。方法:汇总统计2010-2011年我院上报的482例ADR,对患者情况、药品种类、药物成分、药物辅料、累及器官或系统及临床表现等进行统计、分析。结果:482例ADR报告中涉及的药物品种共有146种,其中抗感染药34种(23.29%),居引发ADR的品种数的首位;紫杉醇注射液、复方氨基酸注射液、参麦注射液引发ADR的数量分别位居前3位;ADR主要为全身性损害。结论:临床应关注药物的分子量和注射剂所用辅料,了解药品不良反应发生机制,加强ADR监测报告工作,以确保药物治疗安全、有效。

OBJECTIVE： To investigate the characteristics and regular pattern of adverse drug reactions （ADR） occurred in our hospital to promote rational drug use in the clinic. METHODS： 482 cases of ADR reported during 2010-2011 in our hospital were summarized, and patient’s condition, category of drugs, drug ingredients, drug excipients, organs or systems involved and clinical manifestation were analyzed statistically. RESULTS： There were 146 species of drug involved in the 482 ADR cases, among which 34 species of anti-infection drugs were included （23.29%）, ranking in the top place in terms of number of varieties; Paclitaxel injection, Compound amino acids and Shenmai injection were the top 3 in all drugs induced ADR. Systemic injury was main ADR. CONCLUSION： Great importance should be attached to molecular weight and excipient of injection and the understanding of ADR mechanism, and ADR monitoring should be strengthened so as to ensure safe and effective medication.