β受体阻断药与血管紧张素转换酶抑制药联合用于慢性心力衰竭的临床疗效观察

To Observe of the Effect of βB and ACEI in Their Combined Use in Treating Chronic Heart Failure

目的:观察β受体阻断药(βB)与血管紧张素转换酶抑制药(ACEI)联合治疗慢性心力衰竭的疗效。方法:选择2009年2月-2010年2月康达医院收治的慢性心力衰竭患者102例,随机分为治疗组和对照组。两组均在给予利尿药和强心苷类药的基础上,使用ACEI,治疗组再联合加用βB。治疗6个月后,观察两组状况。结果:治疗组心功能改善总有效率90.38%,对照组72.00%,两组比较差异有统计学意义(P<0.05);治疗组治疗后较治疗前LVESD、LVEDD减少,6min步行试验运动耐量提高,与对照组比较,差异有统计学意义(P<0.05)。结论:在常规抗心衰治疗的基础上联合使用ACEI与βB可获得更好的协同疗效。

Objective：To observe the therapeutic effect of the combined treatment of βB and ACEI.Methods：To randomly divide 102 patients into treatment group and control group.Both groups are given diuretic,cardiac glycoside and ACEI;the treatment group are given βB besides the above-mentioned medicines：the conditions of the groups are compared with each other after 6 months of treatment.Results：The total effective rate of the improvement of heart function in the treatment group is 90.38%,while it is 72.00% in the control group.The comparison has statistic meaning（P0.05）.After the treatment,patients＇ left ventricular end-systolic diameter and left ventricular end-diastolic diameter decrease,patients＇ stamina in the 6-minutes-walk experiment has increased.The comparison has statistic meaning（P0.05）.Conclusion：The combined use of βB and ACEI can get a better treatment effect on the basis of conventional heart failure treatment.