全亲水丙烯酰胺/丙烯酸类梳型聚合物的合成及双重响应性聚集行为

Synthesis and Dual-Responsive Assembling Behavior of Double Hydrophilic Acrylamide/Acrylic Acid Comb-Like Polymers

以引发剂量的壳聚糖(CS)为母体骨架,通过与丙烯酰胺(AM)和丙烯酸(AA)连续的自由基聚合反应,制备了一种全亲水丙烯酰胺/丙烯酸类梳型聚合物(CS-PAM/PAA).聚合物中丙烯酰胺和丙烯酸的组成比例可通过控制反应时间调节,并可通过核磁共振碳谱定量计算.该聚合物具有全亲水嵌段共聚物的特性,在水溶液中具有良好的pH响应性和离子响应性.聚合物溶于水并在酸性条件下自组装形成囊泡结构的聚集体,多价金属离子(如Tb3+离子)也可以引起聚合物的响应聚集.

Double hydrophilic acrylamide/acryl acid comb-like polymers（CS-PAM/PAA） were successfully developed via successive radical polymerization of acrylamide（AM） and acrylic acid（AA） in which triggered amount chitosan（CS） was employed as backbone.The composition of AM and AA in polymers could be regulated by controlling the reaction time,while the ratio was elucidated roughly by 13CNMR in a quantitative way.The polymers showed the typical properties of double hydrophilic block copolymers.Both good pH sensitivity and ion responsiveness were displayed by the polymers aqueous solutions.CS-PAM/PAA could molecularly dissolve in water and self-assemble into vesicular aggregates in the acid condition.In addition,the responsive assembling behavior of polymers could also be induced by multivalent metal ions（e.g.Tb3＋）.