VEGF-C在NSCLC中的表达及其临床意义

Expression and clinical significance of VEGF-C in non-small cell lung cancer

目的血管内皮生长因子-C(VEGF-C)倾向于扩散至淋巴系统,被认为是最具特异性的淋巴管生成调控因子。本研究旨在探讨VEGF-C在非小细胞肺癌中的表达及临床意义。方法采用免疫组化检测70例非小细胞肺癌标本中VEGF-C的表达,以癌旁组织19例、正常肺组织20例为对照。结果 VEGF-C在NSCLC中的阳性表达率为78.6%,明显高于在癌旁组织和正常肺组织的表达;淋巴结转移组的肺癌标本中VEGF-C阳性表达率明显高于在无淋巴结转移组肺癌中表达率;低分化组的肺癌标本中VEGF-C阳性表达率高于在中高分化组中表达率。Logistic回归分析显示肿瘤组织分化程度是VEGF-C蛋白阳性表达影响因素。结论 VEGF-C在肺癌中有较高的表达率,且与淋巴结转移密切相关,提示VEGF-C与肺癌的发生、侵袭和转移存在相关性,可作为评估肺癌进展客观指标及预测肺癌淋巴转移的标志物。

Objective Vascular endothelial growth factor-C has been considered the most specific lymphangiogenesis mod- ulator, tending to spread to the lymphatic system. The aim of this work is to explore the expression of VEGF-C and its clinical significance in non-small cell lung cancer. Methods A total of 70 NSCLC specimens were constructed into tissue mieroarray, 19 cases adjacent tissues and 20 cases normal lung tissue as control, all performed using immunohistochem- istry. Results VEGF-C expression in NSCLC was significantly higher than that in adjacent tissues and normal lung tissues. The VEGF-C positive expression in lymph node metastasis group was significantly higher than that in no-lymph node metastasis. VEGF-C protein positive expression of WD/MD cancer tissue was significantly lower than those in PD/ND can- cer tissue. Logistic regression analysis showed that the histological differentiation degree was one of influencing factors of VEGF-C protein expression. Conclusion There is highly over expression rate of VEGF-C, and close correlation with lym- phnode metastasis in NSCLC, which implies that the VEGF-C expression may be related to tumorgenesis, and metastasis of lung cancer. VEGF-C may he an objective indicator assessing the development of lung cancer and a marker for predicting lymphatic metastasis.