噻托溴铵联合双水平无创正压通气治疗Ⅱ型呼吸衰竭的临床观察

Clinical observation on the combination of tiotropium and bi-level non-invasive positive pressure ventilation in treatment of the type Ⅱ respiratory failure

目的观察噻托溴铵联合双水平无创正压通气治疗Ⅱ型呼吸衰竭效果。方法 50例Ⅱ型呼吸衰竭患者随机分组,对照组采用常规治疗,实验组在常规治疗的基础上采用噻托溴铵联合双水平无创正压通气治疗。观察两组患者的治疗效果、血气分析指标、肺功能指标和预后指标。结果实验组治疗有效率好于对照组,差异有统计学意义(P<0.05)。治疗后,实验组血气分析指标和肺功能指标以及其他与治疗相关指标均较对照组明显改善,差异均有统计学意义(P<0.05)。结论联用噻托溴铵和双水平无创正压通气治疗Ⅱ型呼吸衰竭能改善血气分析指标和呼吸功能,提高治疗效果。

Objective To investigate the therapeutic effects of the combination of tiotropium and bi-level non-invasive positive pressure ventilation in treatment of type Ⅱ respiratory failure. Methods Fifty patients with type Ⅱ of respiratory failure were divided randomly into the experimental and control group, the control group was treated with conventional therapy, and the experimental group was treated with the combination of tiotropium and bi-level noninvasive positive pressure ventilation besides conventional therapy. The blood gas analysis, pulmonary function and prognostic indicators were observed too. Results The rate of total clinical effects in the experimental was higher than the control group （P 〈 0.05）. After treatment, the blood gas analysis, pulmonary function and the other treatment related incidators in the experimental group were significantly improved in the control group with significant difference（P 〈 0.05 ）. Conclusion The combination of tiotropium and bi-level non-invasive positive pressure ventilation in treatment of the type Ⅱ respiratory failure can improve blood gas index and respiratory function to improve the therapeutic effects.