甲钴胺和硫辛酸治疗2型糖尿病周围神经病变的疗效分析

The efficacy differences and preliminary study of type 2 diabetes peripheral neuropathy treated with methylcobalamin and lipoic acid

目的探讨甲钴胺和硫辛酸联合应用对2型糖尿病周围神经病变的治疗效果及其机制。方法选取来我院进行治疗的2型糖尿病周围神经病变患者110例,采用随机数字表法分为实验组和对照组各55例。所有的患者均采取饮食控制及降血糖的治疗措施。实验组在以上基础上给予甲钴胺及硫辛酸治疗,对照组在此基础上给予维生素B12及复方丹参注射液进行治疗,比较两组患者的治疗效果及神经传导速度治疗前后的差异。结果实验组的治疗有效率明显高于对照组,差异具有统计学意义(P<0.05);治疗后实验组尺神经、正中神经及胫神经的传导速度明显高于对照组,差异具有统计学意义(P<0.05)。两组患者均没有明显的不良反应。结论 2型糖尿病周围神经病变患者给予甲钴胺和硫辛酸联合治疗能够收到较为满意的效果,可以作为一种有效的治疗措施在临床推广应用。

Objective To investigate The efficacy of type 2 diabetes peripheral neuropathy treated with methylcobalamin and lipoic acid. Methods A total of 110 patients of type 2 diabetic peripheral neuropathy in our hospital for treatment were selected, they were randomly divided into experimental group and the control group （n = 55）. All patients were given diet control and hypoglycemic. The experimental group was given methylcobalamin and lipoic acid on the basis of the above for treatment, control group was given vitamin B12 and Danshen injection on the basis of the above for treatment, We compared the therapeutic effect of the two groups and nerve conduction velocity differences before and after treatment. Resuits The efficiency of the experimental group was significantly higher than that of the control group, the difference was statistically significant （P 〈 0.05）; After treatment, the ulnar nerve, median nerve and tibial nerve conduction velocity in experimental group were significantly higher than those in the control group, with statistically significant difference （P 〈 0.05）. There were no significant adverse reactions in both groups. Conclusion Type 2 diabetic peripheral neuropathy patients given combination therapy the methylcobalamin and lipoic acid to be able to receive more satisfactory results can be used as an effective treatment in clinical application.