内脂素、Vaspin与糖尿病外周血管病变相关研究
摘要
新的脂肪细胞因子内脂素(visfatin)和内脏脂肪特异性丝氨酸蛋白酶抑制剂(Vaspin)与胰岛素抵抗、糖尿病、代谢综合征等内分泌疾病密切相关。系统性动脉粥样硬化等大血管病变是糖尿病的主要死亡原因。本文对内脂素、Vaspin这两个细胞因子与糖尿病性大血管病变的相关性研究结果作了全面综述。
出处
《求医问药(下半月刊)》
2012年第9期16-17,共2页
Seek Medical and Ask The Medicine
参考文献7
-
1刘军,查英,王芳,陈灶萍,徐炯,盛励,许火根,廖晓寰,郭瑜琳.2型糖尿病非糖尿病一级亲属中肥胖患者血浆内脂素水平[J].中华内分泌代谢杂志,2007,23(4):323-324. 被引量:5
-
2杨媚,杨刚毅,李伶,李清明,阮华玲,阳皓,李钶,孙勤,唐毅,Gunther Boden.不同糖耐量个体血浆内脂素水平的变化[J].中华内分泌代谢杂志,2006,22(3):245-247. 被引量:76
-
3Fukuhara A,Matsuda M,Nishizawa M,et al.Visfatin: a protein secreted by visceral fat that mimics the effects of insulin[].Science.2005
-
4Chang YC,Chang TJ,Lee WJ,et a1.The relationship of visfatin/pre-B-cell colony-enhancing factor/nicotinamide phosphoribosyltransf-erase in adipose tissue with inflammation, insulin resistance, andplasma lipids[].Metabolism.2010
-
5BL Tan,D Heutling,J Chen,S Farhatullah,R Adya,SD Keay,CR Kennedy,H Lehnert,HS Randeva.Metformin decreases the adipokine vaspin in overweight women with polycystic ovary syndrome concomitant with improvement in insulin sensitivity and a decrease in insulin resistance[].Diabetes.2008
-
6Suleymanoglu S,Tascilar E,Pirgon O, et a1.Vaspin and its correlation with insulin sensitivity indices in obese children[].Diabetes Research and Clinical Practice.2009
-
7Nese Ersoz G,Jale K,Arzu G, et a1.Serum vaspin levels in type2diabetic womenin relation to microvascular complications[].European Journal of Endocrinology.2009
二级参考文献19
-
1向光大,何玉生,蒋文,胡泰洪.女性2型糖尿病患者载脂蛋白e4等位基因与内皮依赖性血管舒张功能降低有关[J].中华内分泌代谢杂志,2005,21(1):9-12. 被引量:9
-
2杨媚,杨刚毅,李伶,李清明,阮华玲,阳皓,李钶,孙勤,唐毅,Gunther Boden.不同糖耐量个体血浆内脂素水平的变化[J].中华内分泌代谢杂志,2006,22(3):245-247. 被引量:76
-
3Trayhum P, Beattie JH. Physiological role of adipose tissue: white adipose tissue as an endocrine and secretory organ. Proc Nutr Soc,2001,60:329-339.
-
4Hug C, Lodish HF. Visfatin: A new adipokine. Science, 2005,307:366-367.
-
5Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin: A protein secreted by visceral fat that mimics the effects of insulin. Science, 2005,307:426-430.
-
6Chen MP, Chung FM, Chang DM, et al. Elevated plasma level of visfatin/pre-B cell colony-enhancing factor in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab, 2006,91:295-299.
-
7Kralisch S, Klein J, Lossner U, et al. Hormonal regulation of the novel adipocytokine visfatin in 3T3-L1 adipocytes. J Endocrinol, 2005,185:R1-8.
-
8Berndt J, Kloting N, Kralisch S, et al. Plasma visfatin concentrations and fat depot-specific mRNA expression in humans. Diabetes, 2005,54:2911-2916.
-
9Sethi JK, Vidal-Puig A. Visfatin: the missing link between intra-abdominal obesity and diabetes? Trends Mol Med, 2005,6:45-50.
-
10Fukuhara A, Matsuda M, Nishizawa M, et al. Visfatin : a protein secreted by visceral fat that mimics the effects of insulin. Science, 2005,307:426-430.
共引文献78
-
1温彩珍,成兴波.内脂素研究进展[J].中华内科杂志,2007,46(1):78-80. 被引量:2
-
2周笑漪,徐焱成.高脂饮食诱导的胰岛素抵抗大鼠内脂素的表达水平[J].武汉大学学报(医学版),2007,28(3):324-328. 被引量:9
-
3刘军,查英,王芳,陈灶萍,徐炯,盛励,许火根,廖晓寰,郭瑜琳.2型糖尿病非糖尿病一级亲属中肥胖患者血浆内脂素水平[J].中华内分泌代谢杂志,2007,23(4):323-324. 被引量:5
-
4蒋凤秀,毕娅欣.内脂素的研究进展[J].解剖与临床,2008,13(1):63-64. 被引量:2
-
5温彩珍,成兴波.2型糖尿病患者血浆内脂素水平的变化[J].江苏医药,2008,34(3):293-294. 被引量:1
-
6康丽丽,樊继援.Visfatin与糖尿病关系的研究进展[J].天津医科大学学报,2008,14(1):131-133. 被引量:4
-
7刘军,查英,王芳,陈灶萍,徐炯,盛励,廖晓寰,郭瑜琳.2型糖尿病患者内脏素水平与胰岛素抵抗、胰岛β细胞功能之间的关系[J].临床内科杂志,2008,25(5):333-335. 被引量:3
-
8李颖,翁锡全,林文弢.高脂饮食诱导胰岛素抵抗模型大鼠血清内脂素变化[J].中国组织工程研究与临床康复,2008,12(24):4693-4696. 被引量:9
-
9李清明,杨刚毅,李伶,李钶,齐晓亚,谭兴蓉,石绍川,刘桦,Guenther Boden.Exendin-4改善胰岛素抵抗的作用机制研究[J].中国糖尿病杂志,2008,16(7):405-408. 被引量:3
-
10李仁哲,杨刚毅,李伶,孙勤,刘建雷,石绍川,程玉兰.visfatin对大鼠肝脏胆固醇代谢及SREBP-2的调控作用[J].第四军医大学学报,2008,29(15):1382-1384. 被引量:4
-
1李冰,闫宏,张阳德.血清vaspin水平与冠心病的相关性研究[J].中国现代医学杂志,2012,22(33):72-75. 被引量:6
-
2李海英,秦继宝,安仲武,王波.2型糖尿病患者血清脂肪特异性丝氨酸蛋白酶抑制剂与糖脂代谢的相关性研究[J].中国实验诊断学,2012,16(3):460-462. 被引量:7
-
3王馨,张琳,张晓东,安健.急性冠状动脉综合征患者血浆网膜素-1、内脏脂肪特异性丝氨酸蛋白酶抑制剂水平变化[J].中国循环杂志,2016,31(5):446-448. 被引量:7
-
4刘平,刘波,门晓彦,王迪,李莉,刘博伟,杨艳玲.Vaspin与2型糖尿病肾病的相关性研究[J].中国全科医学,2015,18(35):4306-4309. 被引量:6
-
5朱慧静,成兴波,鲁燕.单纯性肥胖者血清Vaspin水平与胰岛素抵抗的相关性[J].江苏医药,2010,36(8):892-894. 被引量:9
-
6刘平,刘波,王迪,门晓彦,李莉,刘博伟,杨艳玲.糖尿病肾病患者血清脂肪特异性丝氨酸蛋白酶抑制剂水平及其相关因素的研究[J].中国临床医生杂志,2015,43(11):30-32. 被引量:4
-
7刘师伟,王明明,杜芳,李欣,张丽,王军,尚慧锋,傅葵.2型糖尿病患者血清Irisin和Vaspin水平与代谢综合征临床表型的关系[J].中华临床营养杂志,2017,25(1):29-35. 被引量:18
-
8胡鹏,汪兰,李振龙,曹学敏.Vaspin在不同类型和病变支数冠心病患者中的表达及临床意义[J].浙江临床医学,2016,18(3):493-494. 被引量:3
-
9黄仕鹏,刘建英.vaspin与肥胖及2型糖尿病相关性研究进展[J].中国糖尿病杂志,2012,20(9):713-715. 被引量:6
-
10虞建新,吴奇,周理兰.辛伐他汀治疗2型糖尿病伴血脂异常患者的疗效及对血清vaspin水平的影响[J].中国老年学杂志,2014,34(23):6588-6589. 被引量:8