缺血后适应保护pH值假说的研究进展
摘要
对急性心肌梗死患者而言,早期有效地恢复血流供应对其预后十分关键,但是再灌注本身却导致了缺血再灌注损伤。MURRY等提出了缺血预适应(ischemic preconditioning,IPC)的概念,这能起到一定的对抗心肌再灌注损伤的作用。但是,临床上心肌梗死的发生通常是无法预知的,因此,
出处
《广东医学》
CAS
CSCD
北大核心
2012年第22期3490-3492,共3页
Guangdong Medical Journal
基金
国家自然科学基金资助项目(编号:81160019)
参考文献31
-
1YELLON D M,HAUSENLOY D J. Myocardial reperfusion injury[J]. N Engl J Med, 2007,357(11): 1121 -1135.
-
2MURRY C E, JENNINGS R B, REIMER K A. Precondi'tiongingwith ischemia: a delay of lethal cell injury in ischemic myocardium[J]. Circulation, 1986, 74(5) : 1124-1136.
-
3ZHAO Z Q, CERVERA J S, HALKOS M E, et al. Inhibition ofmyocardial injury by ischemic postconditioning during reperfusion:comparion with ischemic preconditioning [ J ] . Am J Physiol HeartCirc Physiol, 2003,285(2) : 579 -588.
-
4COHEN M V, YANG X M, DOWNEY J M. The pH hypothesis ofpostconditioning : staccato reperfusion reintroduces oxygen and per-petuates myocardial acidosis [ J ] . Ciuculation,2007,115 (14 ):1895 -1903.
-
5INSERTE J, BARBA I,HERNANDO V,et al. Effect of acidicreperfusion on prolongation of intracellular acidosis and myocardialsalvage[ J]. Cardiovasc Res, 2008,77(4) : 782 -790.
-
6INSERTE J, BARBA I,HERNANDO V, et al. Delayed recoveryof intracellular acidosis during reperfusion prevents calpain activa-tion and determines protection in postconditioned myocardium[ J].Cardiovasc Res, 2009,81(1):116- 122.
-
7PIPER H M, ABDALLAH Y, SCHAFER C. The first minutes ofreperfusion: a wiondow of opportunity for cardioprotection [ J ].Cardiovasc Res, 2004, 61(3) : 365 -371.
-
8INSERTE J, GARCIA DORADO D, RUIZ MEANA M,et al.Effect of inhibition of Na + /Ca2+ exchanger at the time of myocar-dial reperfusion on hypercontracture and cell death[ J] . CardiovascRes, 2002, 55(4) : 739 -748.
-
9VAUGHAN JONES R D, SPITZER K W, SWIETACH P. Intra-cellular pH regulation in heart [J]. J Mol Cell Cardiol, 2009, 46(3): 318 -331.
-
10HALESTRAP A P. A pore way to die: the role of mitochondria inreperfusion injury and cardioprotection [ J]. Biochem Soc Trans,2010,38(4) : 841 -860.
-
1王轶,漆平,杜光会,王海莲.麝香保心丸治疗冠心病心绞痛的疗效观察[J].中西医结合心血管病电子杂志,2015,3(14):130-132. 被引量:3
-
2张雪媛.健康教育在急性心肌梗死中的应用[J].牡丹江医学院学报,2011,32(6):58-59. 被引量:1
-
3尹素梅.急性脑梗死患者发热的分析与护理对策[J].齐齐哈尔医学院学报,2009,30(18):2330-2331. 被引量:1
-
4何飞连,桂春.缺血性心脏病侧支血管形成的研究进展[J].实用医学杂志,2015,31(22):3672-3674. 被引量:8
-
5马生山.冠状动脉狭窄或闭塞侧支循环18例分析[J].中国误诊学杂志,2008,8(9):2222-2223.
-
6周立红,张春凤,李威颖.丁咯地尔治疗糖尿病周围神经病变的临床观察[J].黑龙江医学,2000(11):49-50.
-
7李长云,马玉琛,申燕.类风湿关节炎的超声表现与中西医治疗[J].医学信息(医药版),2010(10):34-36.
-
8荣锦.颈动脉狭窄怎么治[J].大家健康,2016,0(3):18-18.
-
9杨天宝(综述),康明强(审校).肺缺血再灌注损伤的机制及保护[J].中国保健营养(临床医学学刊),2008,17(10):38-40. 被引量:1
-
10余东彪,吴继雄.他汀类药物在冠心病PCI围手术期的应用及研究进展[J].实用医学杂志,2011,27(18):3432-3433. 被引量:10