热致相分离法制备聚乳酸/聚己内酯多孔支架材料

Preparation of Poly (L-lactic acid)/Poly(caprolactone) Porous Scaffolds by Thermally Induced Phase Separation

以聚乳酸(PLLA)和聚己内酯(PCL)为原料,四氢呋喃(THF)和1,4-二氧六环(DOX)二元组分为溶剂,采用热致相分离技术制备了多孔组织工程支架材料.系统地研究了溶质组成、溶液质量分数、淬火温度及时间等条件对多孔材料微观形貌的影响.实验结果表明:质量分数2%的聚合物溶液(VTHF∶VDOX=1∶1)在-50℃淬火2h,所得多孔支架材料由纤维组成,孔隙明显.

A novel poly （L-lactic acid） （PLLA）/poly （caprolactone） fold was prepared by thermally induced phase separation from their tetrahydrofuran （THF） / dioxane （DOX） solution. The effects of variables such as solute type, polymer concentration, quenching time and temperature on the morphology of scaffolds were studied. The resuits indicated that the optimal parameters for fabricating scaffolds with large interconnected pores were quenching at -50 ℃ [or 2 h of 2% PLLA/PCL in 1：1 （VTHF ： VDOX） solvent mixture.