龙船花的化学成分研究

Study on chemical constituents from Ixora chinensis

目的研究龙船花Ixora chinensis的化学成分。方法用硅胶柱色谱、重结晶等方法进行分离纯化,根据理化性质和波谱数据鉴定结构。结果从龙船花乙醇提取物的石油醚部位和醋酸乙酯部位分离得到7个化合物,分别鉴定为D-甘露醇(1)、十八酸(2)、1,5-环辛二烯(3)、β-谷甾醇(4)、(10E)-9-oxooctadec-10-en-12-ynoic acid(5)、壬二酸(6)、dihydromasticadienolic acid(7)。结论化合物5为新化合物,命名为龙船花脂酸(ixoraliphatic acid)。其他化合物均为首次从龙船花中分离得到,其中D-甘露醇在干药材中质量分数高达0.32%。

Objective To study the chemical constituents ofIxora chinensis. Methods The chemical constituents were isolated and purified by silica gel column chromatography and recrystallization, and the structures were identified by physicochemical properties and spectral analysis method. Results Seven compounds were isolated from PE and EtOH fractions of I. chinensis, and were identified as D-mannitol （1）, stearic acid （2）, 1, 5-cyclooctadiene （3）, β-sitosterol （4）, （10E）-9-oxooctadec-10-en-12-ynoic acid （5）, azelaic acid （6）, and dihydromasticadienolic acid （7）. Conclusion Compound 5, named ixoraliphatic acid, is new and the other compounds are firstly isolated from this plant. The content of D-mannitol in dried I. chinensis reaches up to 0.32%.