全胚冷冻后行冻融胚胎移植预防卵巢过度刺激综合征的临床观察

Clinical observation on preventing ovarian hyperstimulation syndrome by frozen-thawed embryo transfer after all embryo freezing

目的:比较全胚冷冻后行冻融胚胎移植(FET)和常规体外受精-胚胎移植(IVF-ET)的临床妊娠结局,探讨预防卵巢过度刺激综合征(OHSS)的临床应用。方法:回顾性分析IVF-ET过程中为防止中、重度OHSS而行FET的124例患者和常规长方案IVF-ET987例患者的临床资料,比较其胚胎种植率、临床妊娠率。结果:2组的年龄、不孕年限、体重指数差异无统计学意义(P>0.05),移植胚胎个数、胚胎种植率、临床妊娠率差异亦无统计学意义(P>0.05)。IVF组移植后有25例患者因重度OHSS发生而住院治疗,冷冻组无一例住院治疗。结论:全胚冷冻后行冻融胚胎移植可以获得良好的妊娠结局,是一项安全的预防中、重度卵巢过度刺激综合征的临床应用方案。

Objective：To compare the clinical pregnancy outcomes of frozen-thawed embryo transfer（FET） after all embryo freezing and routine in-vitro fertilization and embryo transfer（IVF-ET）,and explore the clinical application for prevention of ovarian hyperstimulation syndrome（OHSS）.Methods：The clinical data of 124 patients receiving FET to prevent moderate and severe OHSS and 987 patients receiving routine long protocol of IVF-ET were analyzed retrospectively,the embryo implantation rates and clinical pregnancy rates in the two groups were compared.Results：There was no statistically significant difference in age,duration of infertility,body mass index,the number of transferred embryos,embryo implantation rate,and clinical pregnancy rate between the two groups（P0.05）,After IVF-ET,25 patients in patients receiving IVF,went to hospital for treatment because of severe OHSS,and no one in patients receiving FET went to hospital.Conclusion：FET after all embryo freezing can achieve a good pregnancy outcome,which is a safe clinical application scheme for preventing moderate and severe OHSS.