摘要
[目的]研究药食植物玛咖与3种天然植物辅料粉末的性质和复合玛咖粉末直接压片的工艺参数。[方法]采用单因子和正交实验设计法,以松密度和振实密度、休止角、溶胀性等对粉体性质进行考察,应用SAS软件分析数据。[结果]天然植物A、B与玛咖粉末的充填性好,流动性对复合玛咖粉体粉末的分剂量产生重要影响;植物A、B粉末为辅料对玛咖的松密度有显著影响(P=0.0125),对溶胀体积比有极显著的影响(P=0.0089),而对玛咖的振实密度(g/ml)影响不大;复合玛咖粉末的溶胀体积比最适宜工艺条件是:A为0.15份,B为0.10份,C为0.05份,其溶胀体积比为2.459。[结论]该工艺处方合理、充填性好,溶胀性、流动性好,可为工业化生产的处方筛选和工艺提供理论依据。
[Objective] The aim was to research property of maca and three plants' powders and process parameters of compound maca direct compression. [Method] Based on analysis data from SAS, bulk density, tap density, angle of repose and swelling of powders were studied as per single factor method and orthogonal exper- imental design. [Result] The test indicated that fillibilities of plant A and B, and maca powders are better and flowability plays an important role in fractional close of compound maca powder; plant A and B powders have a significant effect on bulk density of maca (P=0.0125), an extremely significant effect on swelling volume ratio (P=0.008 9) and little effect on tap density (g/ml); the optimal process condition of compound maca powder is as follows: A at 0.15 share; B at 0.10 share; C at 0.05 share; the optimal swelling volume ratio is at 2.459. [Conclusion] The technology is reasonable in formulation and satisfactory in fillibility, swelling ability, flowability, and it could serve as theoretical basis for the industrial production of maca tablets.
基金
Supported by Special Funds of National Technological and Basic Work(2006FY110700)
Yunnan Province Improvement Project(2007C0219Z)
Special Funds of Biological Industry of Yunnan Financial Development([2011]274)~~