摘要
目的:研究丹参滴注液与头孢西丁钠的配伍稳定性。方法:在模拟临床用药浓度条件下,考察丹参滴注液与头孢西丁钠配伍后溶液的外观、pH、不溶性微粒的变化,采用高效液相色谱法测定配伍后4 h内丹参素钠、原儿茶醛和头孢西丁的含量。结果:4 h内配伍液的外观、pH无明显改变。随着时间的延长,不溶性微粒数增多,三者的含量均逐渐降低。结论:丹参滴注液与头孢西丁钠配伍后4 h内不稳定,不建议配伍使用。
Objective: To investigate the compatible stability of danshen dripping solution and cefoxintin sodium. Method: The content of sodium danshensu, protocateehualdehyde and eefoxintin were determined after compatibility of danshen dripping solution and cefoxintin sodium within 4 hours by HPLC, and the Change8 of solution color, pH value and insoluble particles were observed in the simulation conditions of clinical concentration. Result: The solution eolor and pH value showed no obvious ehanges. The number of insoluble particles was increased and the content of sodium danshensu, protoeatechualdehyde and cefoxintin were reduced with the extending of compatible time. Conclusion: The solution was. unstable after compatibility of danshen dripping solution and cefoxintin sodium within 4 hours, therefore, not suggesting to compatibility use.
出处
《中国实验方剂学杂志》
CAS
北大核心
2012年第23期120-122,共3页
Chinese Journal of Experimental Traditional Medical Formulae
关键词
丹参滴注液
头孢西丁钠
丹参素钠
原儿茶醛
头孢西丁
配伍稳定性
danshen dripping solution
cefoxintin sodium for injection
sodium danshensu
protocatechualdehyde
cefoxintin
Compatible stability