地诺前列酮用于羊水偏少促宫颈成熟的临床观察

Clinical Observation on Propess for Cervical Ripening of Oligohydramnios

【目的】探讨地诺前列酮（PGE2，欣普贝生）用于足月妊娠羊水偏少促宫颈成熟的安全性及有效性。【方法】对212例羊水偏少符合促宫颈成熟指征，无引产及用药禁忌证的足月妊娠孕妇随机分为两组：催产素组（n=102）和欣普贝生组（n=110），催产素组静脉点滴催产素，欣普贝生组阴道后穹隆放置欣普贝生。观察两组促宫颈成熟的安全性及有效性。【结果】欣普贝生组用于羊水偏少引产，促宫颈成熟有效率高，总产程短，阴道分娩率高（P〈0．01），对新生儿不良影响小；但需要密切观察宫缩及胎心，以防胎儿窘迫的发生。【结论】欣普贝生用于足月妊娠羊水偏少引产安全、有效。

[Objective] To explore the safety and efficiency of prostaglandin E2（PGR2, propess） for cervi- cal ripening of oligohydramnios in full-term pregnancy. [Methods] Totally 212 full-tem pregnant women with oligohydramnios corresponding to indications of cervical ripening and without induced labor or medication contraindication were divided into oxytocin group and propess group randomly. Oxytocin group was given intravenous injection of oxytocin. Propess group was placed with propess in posterior fornix. The safety and efficiency for cervical ripening promotion in 2 groups were observed. [Results] Propess group for cervical ripening of oligohydramnios-induced labor had high effective rate, short total labor stage, high vaginal delivery rate and less side effect on neonates. But uterine contraction and fetal heart should be observed closely so as to prevent the incidence of fetal distress. [Conclusion] Propess for oligohydramnios-induced labor in full-term pregnancy is safe and effective.