摘要
目的 :孕激素治疗子宫内膜癌前病变 ,使其转变为正常内膜 ,测定治疗前后子宫内膜雌激素受体和孕激素受体 (ER.PR) ,以了解子宫内膜改变时 ,ER.PR的变化情况。方法 :对 32例癌前病变内膜孕激素治疗前后的石蜡切片 ,采用单克隆抗体免疫组化法测定子宫内膜 ER.PR。结果 :孕激素治疗后 ,子宫内膜由腺瘤样增生或非典型性增生逆转为正常内膜 ER.PR下降 ,前后有显著性差异 (P<0 .0 5 )。结论 :孕激素可有效的阻断子宫内膜癌前病变的恶变 ,并使其逆转为正常内膜 ,同时使子宫内膜 ER.PR下调。
Objective: Treat the endometrium precancerosis with pregnancy hormone, changed the endometrium as the normal mesentery, detect the endometrium estrogen receptor and pregnancy hormone receptor (ER.PR) before and after treatment to know the change of ER.PR when the endometrium have pathological changes. Methods: 32 olefin slices of precancerosis mesentery treated by pregnancy hormone before an after, were detected the ER.PR of endometrium with the monoclonal antibody immunity histochemistry method. Results: After treatment with the pregnancy hormone, endometrium transferred from adenoma hyperplasia or atypism hyperplasia to normal mesentery, ER.PR descended, it has significantly difference before and after ( P <0 05). Conclusion: Pregnancy hormone can block the endometrium precancerosis effectively and made it transfer to normal mesentery, the ER.PR descended.
出处
《中国妇幼保健》
CAS
2000年第3期168-169,共2页
Maternal and Child Health Care of China
基金
河南省科委课题
关键词
子宫内膜
癌前病变
受体
雌激素
孕激素
Endometrium
Precancerosis
Receptor
Estrogen
Pregnancy hormone