乳果糖对肝硬化大鼠血浆内毒素(LPS)肿瘤坏死因子(TNF)及血清ALT的影响研究

Effects of lactulose on plasm lipoplysaccharide endotoxin(LPS), tumor necrosis factor-α(TNF) and ALT in cirrhotic rats

目的:探计乳果糖对肝硬化大鼠血浆内毒素(LPS)、肿瘤坏死因子(TNF)及血清ATL的影响。方法:将四氯化碳(CCL4)注射于SD大鼠皮下,诱导肝硬化伴腹水动物模型。将该鼠随机分为肝硬化模型组、乳果糖治疗组,检测各组和正常鼠的血浆LPS,TNF及血清ALT水平。结果:肝硬化模型组LPS,TNF,ALT水平较正常对照组明显升高;乳果糖治疗组血浆LPSTNFALT水平较肝硬化模型组明显升高;乳果粮治疗组血浆LPS、TNF、ALT水平较肝硬化模型组明显降低。结论:乳果糖能通过降低血浆LPS来显著降低TNF,对肝脏有保护作用。

Objective: To study the effects of lactulose on plasm LPS,TNF in cirrhotic rats Methods: We injected CCL 4 oil solution into subcutane of SD rats to induce cirrhosis animal models with ascites .The rats were randomly divided into cirrhosis model group and treatment group with lactulose, We measured plasm LPS,TNF and serum ALT in every group and normal rats. Results: Cirrhosis,model group had significantly higher plasm LPS TNF ,serum ALT than those of in normal rats ,Lactulose group had significantly lower LPS,TNF,serum ALT levels than those of cirrhosis model group.Conclusion:Lactulse can reduce plasm LPS,TNF and protecthepatic cells.