肠源性内毒素移位后的体内分布

Distribute of enterogenic endotoxin after translocation in vivo

目的 探讨肠源性内毒素移位后在腹膜炎大鼠各脏器中分布。方法 以12 5I-LPS对大鼠灌胃后 ,检测各脏器单位组织重量中内毒素含量。结果 腹膜炎组各主要脏器单位重量中的内毒素含量增加 (P <0 0 5 ) ,由高至低为肾、肺、肝、胰、肠系膜淋巴结、心脏 (P <0 0 5 )。先锋Ⅵ号及多粘菌素B可降低腹膜炎大鼠脏器中内毒素含量。结论 急性感染性腹膜炎可致肠源性内毒素移位增加。腹膜炎时易发生肾衰、呼衰与其单位组织中内毒素含量有关。先锋Ⅵ号、多粘菌素B对肠源性内毒素移位有一定的抑制作用。

Objective To study the distribution of enterogenic endotoxin in peritonitised rats.Method The amount of 125 I-LPS in the unit weight of the each organ are detected. After 125 I-LPS was poured down the stomach of rats.Results Amount of endotoxin in main organs are increase in peritonitised rats ( P <0 05).The order from high to low is kidney ,liver ,lung ,pancreas ,spleen ,mesenterium lymph node ,heart ( P <0 05).Cefesulodin and PolymyxinB can significantly reduce the amount of 125 I-LPS.Conclusions acute infectious peritonitis can increase the translocation of enterogenic endtoxin .Renal failure and respiratory failure are related with the amount of endotoxin in the unit weight of organic tissue .Cefesulodin and PolymyxinB can significantly reduce the mortality and inhibite the translocation of enteroqenic endotoxin in peritonitised rats.[