急性缺血性脑卒中患者血浆脑钠肽水平与神经功能缺失的关系

Clinical analysis of the relationship between the neurologic deficits and plasma brain natriuretic peptide level in acute ischemic stroke patients

目的分析急性缺血性脑卒中患者入院时血浆脑钠肽（BNP）水平与神经功能缺失严重程度的关系。方法随机选择88例急性缺血性脑卒中患者，根据美国国立卫生院神经功能缺损评分（NIHSS）分为急性期神经功能缺失严重组（NIHSS评分≥8分）与急性期神经功能缺失轻症组（NIHSS评分〈8分）两组，测定患者人院时血浆BNP水平并进行比较，将急性缺血性脑卒中患者急性期神经功能缺失严重程度相关的多个变量采用单因素Logistic回归分析。结果入院时NIHSS评分与梗死体积、入院时BNP值均明显相关（P〈0．01），急性期神经功能缺失严重组血浆BNP水平明显高于急性期神经功能缺失轻症组（P〈0．01）。血浆BNP水平≥634．15pg／ml可以作为急性期神经功能缺失较严重（NIHSS评分≥8分）的预测指标，其敏感性为86．96％，特异性为86．15％。结论急性缺血性脑卒中患者入院时血浆BNP水平可作为急性期神经功能缺失严重程度的预测因子。

Objective To analysis the relation between plasma brain natriuretic peptide （BNP） levels on admission and the severity of neurologic deficits in acute ischemie stroke patients. Methods Randomly selected 88 acute ischemic stroke patients with acute phase of neurological deficit. In accord- ance with NIHSS score,patients were divided into two groups：severe group（ NIHSS score ≥ 8 points） and mild group（ NIHSS score 〈 8 ）. Plasma BNP profiles on admission were compared. Univariate logistic re- gression analyzed multiple variables which related to the severity of acute neurological deficits in acute is- chemic stroke patients. Results NIHSS score on admission were significantly related with infarct volume, and BNP grades on admission（ P 〈 0. Ol ）. Compared with mild group, plasma BNP levels were significant- ly higher in severe group（P 〈0.01 ）. When plasma BNP~〉634.15 pg/ml,it can serve as a predictor in acute phase of neurological deficits patients （ NIHSS score≥ 8 points）. The sensitivity was 86.96% and specificity was 86.15%. Conculusion For acute isehemic stroke patients, plasma BNP levels on admis- sion can be viewed as a predictive factor of the severity of acute neurological deficits in acute phase.