摘要
目的研究人源幼虫巨大致死性基因（Hugl）-1在肝癌组织中的表达及其与肝癌临床病理的相关性，探讨Hugl-1的表达与肝癌发生及发展的相关性。方法采用免疫组化SP法检测70例不同类型肝癌标本和5例正常及炎性病变肝组织标本中Hugl-1的表达，并结合临床病理资料进行相关性分析。结果肝癌组织中Hugl-1的表达水平明显低于正常肝组织及炎性病变肝组织，且表达强度随肿瘤病理分级的增高呈降低趋势（P〈0．05）。70例肝癌组织中Hugl-1表达率与患者的性别、年龄、有无淋巴结转移无明显相关（P〉0．05）。结论Hugl-1表达下调与肝癌的发生、发展密切相关，Hugl-1可作为反映肝癌恶性生物学行为的一个有价值的指标。
Objective To investigate the expression of human lethal-giant-lavae 1 （Hugh in hepatic carcinoma, and to explore the correlation between Hugl-1 expression and the development of hepat- ic carcinoma. Methods The expression of Hugl-1 was examined by immunohistochemical staining in 70 hepatic carcinoma and 5 normal hepatic tissues, and the correlation between Hugl-1 expression and clini- copthotogical parameters was analyzed. Results The expression of Hugl-1 was significantly lower in he- parle carcinoma tissues than in normal and inflammatory tissues. The positive expression rate of Hugl-lwas decreased with increasing pathologic grading of cacinoma（ P 〈 0.05 ）. No correlations were found be- tween Hugl-1 and the lymph node metastasis, age and gender in 70 hepatic carcinoma patients （ P 〉 0.05 ）. Conclusion Down regulation of Hugl-I expression contributes to the progression of hepatic carci- noma, and might be a novel tumor marker for liver cancer.
出处
《临床内科杂志》
CAS
2012年第10期710-712,共3页
Journal of Clinical Internal Medicine
基金
中央高校基本科研业务费专项资金资助项目（302274546）
