解脲脲原体和人型支原体实验室检测结果分析

Analysis on laboratory test results of Ureaplasma urealyticum and Mycoplasma hominis

目的:总结分析解脲脲原体和人型支原体实验室检测结果,对比男女患者的感染差异及对常用抗生素的耐药性分析,为临床合理使用抗生素提供用药参考。方法:603例标本来自于2010年6～12月在武警北京市总队第三医院就诊患者,采用支原体培养、药敏一体化试剂盒对603例泌尿生殖道患者标本进行支原体培养、鉴定和药敏试验,结果采用SPSS19.0统计软件,应用χ2检验进行分析。以P<0.05为差异有统计学意义。结果:603例标本总阳性检出率为43.29%;其中Uu单项感染32.34%,Mh单项感染1.33%,Uu和Mh混合感染9.62%。女性检出率大于男性。603例Uu和Mh药物敏感性男女性存在差异。排在前4位的抗生素男女性分别为:男性:米诺环素(96.9%)、多西环素(96.9%)>交沙霉素(92.2%)>克拉霉素(87.5%);女性:米诺环素(96.9%)>多西环素(94.9%)>交沙霉素(74.1%)>克拉霉素(57.3%)。结论:Uu和Mh是引起泌尿生殖道感染的常见病原体,女性感染率高于男性。米诺环素和多西环素可作为治疗泌尿生殖道支原体感染的首选药物。

Objectives： To summarize and analyze the laboratory test results of Ureaplasma urealyticum （Uu） and Myco- plasma hominis （Mh）. Men and women were compared in their infection of Uu and Mh and their antibiotic drug - resistance. Methods： A total of 603 samples were collected from the patients who came to our hospital for treatment between June and De- cember, 2010. The samples were applied with mycoplasma culture. Drug susceptibility integration kit was used to get the result of the culture for bacteria identification and drug sensitivity tests. X2 test was run by SPSS19.0 to analyze the result. Results： A- mong 603 samples, the total positive detection rate was 43.29%, of which 32.34% was Uu infection, 1.33% was Mh infection and 9.62% was mixed infection of Uu and Mh. Females showed higher detection rates than males. Differences in antimicrobial drug sensitivity were found between males and females. For male patients, the resistance rate against minocycline, doxycyclin, josamycine, and clarithromycin were 96.9%, 96.9%, 92.2%, and 87.5%, respectively. For female patients, the resistance rate against the above four antibiotics were 96.9%, 94.9%, 74.1% and 57.3%, respectively. Conclusion： Uu and Mh are the two common pathogens for genitourinary tract infection. Women tend to have a higher infection rate than men. Minocycline and doxycycline are the priority choices for the treatment of genitourinary tract infection.