慢性腹泻首选抗生素治疗利弊的思考

Advantage and Disadvantage of Antibiotics in Treatment of Chronic Diarrhea

:随着预防医学的不断发展和抗菌素的广泛使用 ,人类的疾病谱发生了巨大变化。慢性腹泻病因也由感染为主转变为多元化 ,非感染性原因越来越多。此外 ,随着人们对抗菌素的副作用、细菌耐药问题以及抗菌素所致的菌群失调引起的不良后果的认识不断深入 ,要求临床医生必须重新评价慢性腹泻选用抗菌素治疗的利弊。慢性腹泻病人是否使用抗菌素治疗关键是明确病因诊断 ,而合理选用抗菌素则应以粪便细菌检测作为依据。根据病人肝、肾、心脏功能及全身情况 ,选择特异性强、低价位、副作用小的药物 。

The disease spectrum of human being has been changed greatly,with the constant development of preventing medicine and extensive using of antibiotics.Causion of chronic diarrhea changes to polyarchy from infection,non-infectious factor is more and more.Understanding to side effect of antibiotics,bacteria drug-resistance,and flora imbalance caused by antibiotics is constant thorough,clinician must reevaluate advantages and disadvantage of antibiotics in treatment of chronic diarrhea.Whether using antibiotics in treatment of diarrhea,the key point is making clear the cause of disease,feces bacteral examination is bases of using of antibiotics.According to status of liver,kidney,heart and general condition of patient,choose the drug with high specity,low expension,and low side effect,this is the principle of using antibiotics.