补充精氨酸对热应激大鼠胸腺组织学的影响

Effects of Supplementary Arginine on the Histology of Thymus in Heat stressed Rets

观察通过灌胃补充不同浓度精氨酸的大鼠在常温和不同高温条件下热应激时胸腺的组织学变化。结果显示 ,各组在常温状态下 ,其结构基本一致 ;而在不同温度热应激状态下大鼠胸腺的损伤程度明显不同 ,补充精氨酸两组轻于未补充精氨酸组 ,低温度组轻于高温度组 ,短时间热应激组轻于长时间热应激组 ,而且胸腺的组织学变化随热应激后不同时间有所不同。提示 :不同高温均可造成胸腺结构及其细胞的损伤 ,随着温度的升高和热应激时间的延长其损伤加重 。

We observed the histological changs of thymus in rats which were exposed under normal temperature and different hyperthermoa with supplied different concentration arginine by gavage.The results showed that the structure of thymus in every group revealled no marked difference at normal temperature condition,but the damages degree of thymus structure was obvious difference in the different heat stressed rats.The damages were less in rats with supplementation of arginine groups.low temperature groups and short time heat stressed groups than those with no supplementation of arginine groups,high temperature groups and long time heat stressed groups individually.And that the histological changes of thymus followed the different time after heat stress were different.It suggested that the different hyperthermia all could injury the cells and structure of thymus.As the hyperthermia increased and heat stressed time prolonged,the damages of thymus aggravated.Adequate supplementary arginine could protect the thymus of rats under heat stress.