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血浆8-异前列腺素F2a与糖尿病血管内皮损伤的关系 被引量：4

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摘要 目的探讨血浆8-异前列腺素F2a(8-iso-PGF2a)在糖尿病患者中的表达及与糖尿病血管内皮损伤的关系。方法对2型糖尿病患者按照尿白蛋白/尿肌酐(ACR)进行分组,ACR<30 mg/g为无微量白蛋白尿糖尿病组(DM组);ACR≥30 mg/g为糖尿病肾病组(DN组)。另有正常体检者28例为健康对照组(NC组),ELISA法检测血浆8-iso-PGF2a和血管性假血友病因子(vWF)的水平,分析其相关性。结果 DN组患者血浆8-iso-PGF2a水平为(554.49±134.28)pg/ml,明显高于DM患者〔(386.68±117.10)pg/ml〕,及NC组〔(287.55±108.95)pg/ml〕(P<0.05)。NC组、DM组和DN患者血浆vWF的值分别为(138.12±91.27)%、(193.16±68.58)%、(334.05±49.94)%,三组及组间两两比较差异有统计学意义(P<0.05)。单因素相关分析结果显示8-iso-PGF2a与高敏C反应蛋白(hsCRP)、体重指数(BMI)、甘油三酯(TG)、vWF、ACR呈正相关。结论糖尿病患者体内氧化应激水平升高,且随着糖尿病微血管病变的加重氧化应激进一步增强;在积极控制血糖同时,因尽早合理给予抗氧化、抗凝治疗,保护血管内皮功能可能对延缓糖尿病肾病及其他微血管并发症的发生发展有益。
作者 郑海建 谢燕 王翎
机构地区 赣榆县人民医院老年干部科 苏州大学附属第一医院
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第22期4904-4906,共3页 Chinese Journal of Gerontology
关键词 2型糖尿病 糖尿病肾病 氧化应激 8-异前列腺素F2A 内皮损伤
分类号 R587.1 [医药卫生—内分泌]
  • 相关文献

参考文献14

  • 1Brownlee M.The pathobiology of diabetic complications:a unifying mech-anism[J].Diabetes,2005;54(6):1615-25.
  • 2Mezzetti A,Cipollone F,Cuccurullo F.Oxidative stress and cardiovascular complications in diabetes:isoprostanes as new markers on an old paradigm[J].Cardiovasc Res,2000;47(3):475-88.
  • 3World Health Organization.Definition,dignosis and classification of diabe-tes mellitus and it's complications(D).WHO/NCD/NCS/99.2.
  • 4KDOQI/KDORI.Clinical practice guidelines and clinical practice recom-mendations for diabetes and chronic kidney disease[J].Am J KidneyDis,2007;49(2):S12-154.
  • 5Whiting PH,Kalansooriya A,Holbrook l,et al.The relationship between chronic glycaemic control and oxidative stress in type 2 diabetes mellitus[J].Br J Biomed Sci,2008;65(2):71-4.
  • 6裴薇,逄力男,柳林,吴琰,张金华.8-异前列腺素F2а与早期糖尿病肾病关系的临床研究[J].中国实用医药,2010,5(8):6-8. 被引量：3
  • 7Nobecourt E,Jacqueminet S,Hansel B,et al.Defective antioxidative activ-ity of small dense HDL 3 particles in type 2 diabetes:relationship to ele-vated oxidative stress and hyperglycemia[J].Diabetologia,2005;48(3):529-38.
  • 8Nishikawa T,Araki E.Impact of mitochondrial ROS production in the pathogenesis of diabetes mellitus and its Complications[J].Antioxid Redox Signal,2007;9(3):343-53.
  • 9Erem C,Hacihasanoglu A,Celik S,et al.Coagulation and fibrinolysis pa-rameters in type 2 diabetic patients with and without diabetic vascular complications[J].Med Princ Pract,2005;14(1):22-30.
  • 10方咏红,张继平,周少雄,郑菊芬,余永卫,晏世刚,范文奎,陈月崧.2型糖尿病患者血清血管性血友病因子、血小板活化因子水平与糖尿病肾病的关系[J].第一军医大学学报,2005,25(6):729-731. 被引量：14

二级参考文献28

  • 1张林华,刘秉文.一次性密度梯度超速离心分离人血清脂蛋白[J].生物化学与生物物理学报,1989,21(3):257-260. 被引量：116
  • 2常洁,姜宗培,余学清.氧化应激及其在糖尿病肾病中的作用[J].国际内科学杂志,2007,34(2):105-108. 被引量：25
  • 3Morrow JD,Roberts LJ.Mass spectrometry of prostanoids:F2-isoprostanes produced by non-cyclooxygenase free radical-catalyzed mechanism.Methods Enzymol,1994,233:163-174.
  • 4Zwart LL,Meerman JH,Commandeur JN,et al.Biomarkers of free radical damage:applications in experimental animals and in humans.Free Radic Biol Med,1999,26(1-2):202-226.
  • 5Pratico D,Lawson JA,Rokach J,et al.The isoprostanes in biology and medicine.Trends Endocrinol Metab,2001,12(6):243-247.
  • 6Pratico D.F2-isoprostanes:sensitive and specific non-invasive indices of lipid peroxidation in vivo.Atherosclerosis,1999,147(1):1-10.
  • 7Helmersson J,Vessby B,Larsson A,et al.Association of type 2 diabetes with cyclooxygenase-mediated inflammation and oxidative stress in an elderly population.Circulation,2004,109(14):1729-1734.
  • 8Gopaul NK,Manraj MD,Hebe A,et al.Oxidative stress could precede endothelial dysfunction and insulin resistance in Indian Mauritians with impaired glucose metabolism.Diabetologia,2001,44(6):706-712.
  • 9Davì G,Ciabattoni G,Consoli A,et al.In vivo formation of 8-iso-prostaglandin F2а and platelet activation in diabetes mellitus:effects of improved metabolic control and vitamin E supplementation.Circulation,1999,99(2):224-229.
  • 10Gopaul NK,Halliwell B,Anggard EE.Measurement of plasma F2-isoprostanes as an index of lipid peroxidation does not appear to be confounded by diet.Free Radic Res,2000,33(2):115-127.

共引文献26

同被引文献44

  • 1王小林,张舜.糖尿病微血管病变分析[J].中国疗养医学,2011,20(11):1009-1010. 被引量：6
  • 2陈大春,周东丰,曹连元,谭云龙,李艳丽,王宁,聂鹰,杨可冰,姚付新,张向阳.利培酮和氟哌啶醇对精神分裂症患者超氧化物歧化酶及催乳素影响的临床对照研究[J].中华精神科杂志,2007,40(1):5-9. 被引量：5
  • 3牟海英,马静.8-异前列腺素F_(2α)与氧化应激损伤性疾病的研究进展[J].国外医学（卫生学分册）,2007,34(6):377-381. 被引量：9
  • 4Munshi RP,Joshi SG,Rane BN. Development of an ex- perimental diet model in rats to study hyperlipidemia and insulin resistance, markers for coronary heart disease [J]. Indian J Pharmacol, 2014,46 (3) : 270-276.
  • 5Sedighi O, Makhlough A, Shokrzadeh M, et al. Association between plasma selenium and glutathione peroxidase lev- els and severity of diabetic nephtopathy in patients with type two diabetes mellitus [J]. Nephrourol Mon,2014,6 (5) :e21355.
  • 6Nakanishi S,Yoneda M, Maeda S. Impact of glucose ex- cursion and mean glucose concentration in oral glucose- tolerance test on oxidative stress among Japanese Ameri- cans [J]. Diabetes Metab Syndr Obes, 2013,22 (6) : 427- 433.
  • 7裴晓燕,张晓梅.不同糖调节受损人群氧化应激状况与胰岛素抵抗及胰岛β细胞功能的相关性[J].蚌埠医学院,2012,37(10):1174—1176.
  • 8Neri S, Calvagno S, Mauceri B,et al. Effects of antioxi- dants on postprandial oxidative stress and endothelial dysfunction in subjects with impaired glucose tolerance and type 2 diabetes [J]. Eur J Nutr,2012,49(7) :409-416.
  • 9Du Y,Zhang H, Montano S, et al. Plasma glutaredoxin ac- tivity in healthy subjects and patients with abnormal glu- cose levels or overt type 2 diabetes [J]. Acta Diabetol, 2014,51 (2) : 225-232.
  • 10Ravassa S,Beaumont J,Huerta A,et al. Association of low GLP-1 with oxidative stress is related to cardiac disease and outcome in patients with type 2 diabetes mellitus:a pilot study [J]. Free Radic Biol Med,2015,13(8) : 10-12.

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二级引证文献24

中国老年学杂志
2012年 第22期

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