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老年高血压前期合并糖耐量异常患者颈动脉内中膜的厚度 被引量：3

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摘要 目的分析高血压前期合并糖代谢异常(IGT)老年患者的颈动脉内膜中膜厚度(IMT)改变。方法按照高血压前期和IGT的诊断标准,将研究对象分为:高血压前期组(仅高血压前期,无IGT)72例;IGT组(仅IGT,无高血压前期);高血压前期合并IGT组108例;对照组(无高血压前期和IGT)100例。均测量血压、体重指数(BMI),空腹静脉采血,进行血脂、血糖、肾功能和高敏C反应蛋白(hs-CRP)的测定并进行IMT测量。结果高血压前期组和高血压前期合并IGT组的收缩压和舒张压显著高于IGT组和对照组(P<0.05),IGT组和高血压前期合并IGT组的2h PG显著高于高血压前期组和对照组(P<0.05),高血压前期合并IGT组的hs-CRP和IMT显著高于其余三组(P<0.05)。同时,高血压前期组和IGT组的hs-CRP和IMT均高于对照组(P<0.05)。析因设计的方差分析显示只有hs-CRP和IMT受到血压和血糖交互作用的影响(均P<0.05)。收缩压、舒张压、2 h PG和hs-CRP对IMT有显著影响,回归分析得到方程:IMT=-0.732+0.328(hs-CRP)+0.052(2 h PG)+0.004(收缩压)+0.004(舒张压)。结论 IGT会显著促进老年高血压前期患者的血管损害,老年高血压前期合并IGT患者不但需要控制血压,还需要及时检测自身的血糖变化,并加强早期干预。
作者 王刚 王云超 潘侃达 郁丽娜 张冯江 严敏
机构地区 杭州市萧山第一人民医院重症医学科 浙江大学医学院附属第二医院麻醉科
出处 《中国老年学杂志》 CAS CSCD 北大核心 2012年第22期4908-4910,共3页 Chinese Journal of Gerontology
关键词 高血压 糖代谢异常 内中膜厚度 心血管事件
分类号 R544.1 [医药卫生—心血管疾病]
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参考文献14

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共引文献12

同被引文献31

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引证文献3

二级引证文献11

中国老年学杂志
2012年 第22期

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