大脑内静脉及其属支的磁敏感加权成像研究进展

Susceptibility weighted imaging in the internal cerebral vein and its tributaries

磁敏感加权成像(SWI)是利用不同组织间磁化率的差异产生图像对比。顺磁性的脱氧血红蛋白是静脉显影的内源性对比剂,故对于静脉血管有特殊敏感性,甚至可以检测到小于1个体素(200～300μm)的细微静脉结构。这一新技术的应用,将大大提高隐匿性大脑疾病的检出率。然而,疾病的诊断始终是建立在对正常解剖结构的认识之上的,我们通过回顾SWI技术对静脉成像原理及在静脉系统疾病中的应用研究,结合课题组采用微血管灌注法和磁共振静脉成像(MRV)技术对大脑内静脉(ICV)及其属支的研究结果,综述SWI显示大脑内静脉及其属支研究现状,探讨通过SWI技术构建大脑内静脉及其属支图谱的可行性,为临床相关疾病诊断及治疗提供参考及指导。

Susceptibility weighted imaging（SWI） is a method using magnetizable rate differences between different organizations to attain image contrast. The deoxidizing hemoglobin of the vein is paramagnetic and is a good endogenous enhancement contrast agent, so SWI has special sensitivity for the veins. SWI can detect less than an individual element of the venule （200-300p, m）. The application of this new technology will improve the detection rate of delitescent brain diseases greatly. Understanding of the normal anatomy structure is necessary for disease diagnosis. This article reviews the principle and technology of the SWI for the venous system and the related clinical research, combined with the results of microvascular perfusion method and magnetic resonance venography （MRV） technology on the internal cerebral vein （ICV） and its tributaries, in order to explore the feasibility of using SWI to establish the atlas of ICV and its tributaries and to provide guidance for clinical diagnosis and treatment.