山东沿海地区人群血尿酸水平及其在痛风筛检中的意义

THE LEVEL OF SEMUM URIC ACID AND ITS SIGNIFICANCE IN GOUT SCREENING

目的 :了解山东沿海地区人群血尿酸水平和高尿酸血症患病率 ,为痛风病筛检提供参考。方法 :山东省沿海的日照、东营、威海三市随机抽取 2 0岁以上正常人 384名 ,以在流调中筛查出符合一项以上诊断标准者 74人为高危人群 ,用尿酸酶 /TEINDER法检测血清尿酸含量。结果 :正常人群男性血尿酸均值为 ( 2 89.6± 76.5)μmol/L,女性为 ( 2 36.5± 63.3)μmol/L ( t′=1 .975P<0 .0 5) ;男性高尿酸血症患病率为3.62 % ,女性为 5.2 8%。高危人群男性血尿酸均值为 ( 367.3± 96.4)μmol/L,女性为 ( 2 86.3± 78.9)μmol/L,男性高尿酸血症患病率为 2 1 .5% ,女性为 9.0 9% ,血尿酸均值及高尿酸血症患病率均显著高于正常人群。结论 :提示山东沿海地区人群血尿酸水平明显高于国内既往调查结果。结合痛风流调诊断标准 ,在高危人群中检测血尿酸可显著提高高尿酸血症检出率。

Objective: To study the level of serum uric acid(SUA) and prevalence of hyperuricemia (HUM) among the population on eastrn coast of Shandong Province.Methods: The SUA was detected by uricase/trinder method in a random sample,which consisted of 384 normal adusls and 74 risk people. Results: The mean of SUA was (289.6±76.5)μmol/L in males vs(236±63.3)μmol/L in females in normal adults. There differenceis is significant between males and females (t′=1.975 P<0.05), but there is no significant difference among age groups. The prevalence of HUM was 5.79% in males and 2.44% in females. In adult risk people, the mean of SUA was (367.6±96.4)μmol/L in males vs (286±78.9)μmol/L in females and the prevalence of HUM was 21.5% in males and 9.09% in females. The level of SUA and the prevalence of HUM in risk people were significantly higher than those in normal people.Conclusion: The results suggest that the level of SUA and prevalence of HUM among the population in Shandong Province are significantly lower than the corresponding levels in European and American population. Detecting SUA in risk people may improve screening efficiency of HUM.