盐酸阿比朵尔在大鼠体内的药代动力学

Pharmacokinetics of arbidol hydrochloride in rats

目的研究盐酸阿比朵尔在大鼠体内的药代动力学。方法将健康♂Wistar系大鼠(200～220 g),随机分组,每组6只。单次灌胃给予药物,剂量分别为9、18、54 mg.kg-1,从眼眶静脉丛分时取血、处理。采用高效液相色谱-质谱联用方法测定药物在血浆中的浓度,应用DAS 2.0软件计算主要药代动力学参数。结果按9、18、54 mg.kg-13个剂量分别单次灌胃给予大鼠盐酸阿比朵尔后,药物在动物体内的Cmax分别为644.1、1002、4711μg.L-1;Tmax分别为0.35、0.28、0.18 h;AUC0-t分别为1127、1956、6790μg.h.L-1;AUC0-∞分别为1250、2224、7558μg.h.L-1;T12分别为3.2、3.6、3.3 h。结论以上数据经统计学分析,结果表明:在9～54 mg.kg-1剂量范围内,单剂量灌胃给予大鼠盐酸阿比朵尔后,药物在动物体内的动力学行为具有线性特征。

Aim To investigate the pharmacokinetic characteristics of arbidol hydrochloride in rats.Methods Wister rats were used in this experiment whose body weights ranged from 200 to 220 g.The animals were distributed to three test groups at random（6 for each group）.The pharmacokinetic processes of arbidol in rats after single oral administration at different doses（9,18 and 54 mg·kg-1） were investigated.The blood samples were collected at different time points and then determined with an HPLC-MS analysis method.The main pharmacokinetic parameters were calculated by DAS 2.0 software.Results Under the oral doses of 9,18 and 54 mg·kg-1,Tmax were 0.35,0.28 and 0.18 h;Cmax were 644.1,1002 and 4711 μg·L-1;AUC0-t were 1127,1956 and 6790 μg·h·L-1;AUC0-∞ were 1250,2224 and 7558 μg·h·L-1;T1 2 were 3.2,3.6 and 3.3 h,respectively.Conclution Dose-dependent linear relationship of AUC0-t and Cmax for arbidol is found in the range of 9 to 54 mg·kg-1 after oral administration to rats.T1 2 values from the three groups show no significant difference by rank sum test.