微量元素与恶性淋巴瘤关系的研究

Association Between Malignant Lymphoma and Trace Elememts

目的 探讨微量元素与恶性淋巴瘤发生、发展的关系。方法 采用原子吸收分光光度计对 370例恶性淋巴瘤患者 ,10 0例健康成人进行血清微量元素的测定及分析。结果 恶性淋巴瘤患者组血清铜、铜 /锌比值、锰含量高于对照组 ,而锌、铁、钙含量均低于对照组 ,差异显著 (P <0 0 5～P <0 0 0 1)。结果还表明 ,不同类型何杰金氏病 (HD)患者之间的被测元素变化较大 ,淋巴细胞消减型 (LD)组血清铜和铜 /锌比值高于混合细胞型 (MC)和淋巴细胞为主型 (LP) ,而锌低于混合细胞型 (MC) ,差异显著 (P <0 0 5～P <0 0 0 1)。非何杰金氏病患者中 ,Ⅲ、Ⅳ期组血清铜含量和铜 /锌比值高于Ⅰ、Ⅱ期患者组 ,差异显著 (P <0 0 0 1)。结论 血清中铜、锌、锰、钙及铜 /锌的测定对恶性淋巴瘤患者的病因调查、临床诊断、型态鉴别及其疗效观察可提供重要的依据。本研究资料的Logistic回归的多因素分析表明 ,铁元素和铜 /锌比值相对危险度 (OR)分别为 0 46 34和 10 9919,偏回归系数 (β)为 - 0 76 91和 2 3972 ,95 %可信限 (CI)分别为 (- 1 34 32～ - 0 1949)和 (1 6 0 2 0～3 192 3) ,提示 ,铁可能是恶性淋巴瘤的保护因素 ,而铜

The serum cotents of Cu、Zn、Fe、Mn、Ca and Cu/Zn in370 patients with malignant lymphoma and 100 healthy subjects were determined by atomic absorption spectrphotometry.The result showed that serum Cu、Mn and Cu/Zn were higher and the serum Zn、Fe、Ca were lower in patients with malignant lymphoma than those of the control group,( P <0 05～ P <0 001).In patients with hodgkin malignant lymphoma,the serum Cu Cu/Zn were higher in the patients with LD than those in patients with MC and LP and serum Zn was lower than the patient with LP.The serum Cu and Cu/Zn in the patients with non Hodgkins lymphoma,stage Ⅲ and Ⅳ were higher than those of Ⅰ and Ⅱ patients,stage Ⅰ and Ⅱ( P <0 001,respectively).The muiti variable logistic regression analysis showed the serum Fe and Cu/Zn OR value were 0 4634 and 10 9919,β and 95% Cl Were -0 7691(-1 3432～0 1949) and 2 3972(1 6020～3 1923).These data indicate that serum Cu、Zn、Fe、Mn、Ca and Cu/Zn determination were important evidence for the etiology investigation、clinical diagnosis and curative effect observation of the patients with malignant lymphoma.Our results suggest that Fe in serum may be the protecitve factor and Cu/Zn may be the risk factor of malignant lymphoma.