nm23-H1表达预测大肠癌转移的价值研究

The Value on nm23-H1 Predication of Metastatic Potential in Colorectal Carcinomas

目的 大肠癌预后取决于是否存在肿瘤转移 ,目前尚无肯定的观测大肠癌细胞恶性潜能的生物学指标。本研究目的在于探讨nm2 3 H1作为预测大肠癌转移指标的潜在价值。方法 采用免疫组织化学链霉菌亲合物素蛋白—生物素酶标 (SP)方法对 5 8例存档大肠癌标本进行nm2 3 H1蛋白表达检测 ,用SSPS统计软件包对nm H1表达与临床病理参数的关系进行分析。结果 正常大肠粘膜和大肠腺瘤nm2 3呈阳性表达 ,6 2 1%大肠癌组织阳性表达。nm2 3表达与肿瘤分级、淋巴结及肝转移负相关 (P值分别为 0 0 10 0 ,0 2 0 87,0 0 0 376 )。nm2 3阳性表达的大肠癌患者预后好(P =0 0 0 0 2 )。结论 nm2 3

Objectrive Most deaths from colorectal carcinoma are due to metastasis.However,there is no reliable metastatic potential indicator to date.This study was performed to investigate the potentials of nm23 H1 as metastatic potential markers in colorectal cancer.Method Immunohistologic staining for nm23 H1 was performed on archival materials from 58 patients with colorectal carcinomas by SP assay.The relationship between nm23 H1 expression in tumor tissues and clinicopathological parameters was analyzed using SSPS software.Results 62 1% of patients with colorectal cancer expressed elevated levels of nm23 H1,and correlated with decreasing tumor stage( P =0 01),and had a negative relation with lymph node and liver metastasis( P =0 02087,0 00376,respectively).nm23 H1 as a reliable metastatic potential marker,overexpression of nm23 H1 contributed to good prognosis( P =0 0002) Conclusion nm23 H1 is a sensitive marker for predication of metastatic potential in colorectal carcinomas.