活血通脉片对实验性SD大鼠急性血瘀证血液流变性的影响

Effects of Huoxue Tongmai Tablet on hemorheology of acute blood stagnation in rats

目的 研究中药复方制剂活血通脉片 (HXTMT)对SD大鼠急性血瘀证的影响 .方法 用 HXTMT混悬液给予SD大鼠灌胃 1wk,第 7日同时对大鼠皮下注射 2次 1g·L- 1 肾上腺素 0 .2 m L ,其间进行 1次寒冷刺激 (冰水 ,0℃ ) 5min,于第 8日晨复制成血瘀实验模型 ,并采血测定血液流变学各指标 .结果 HXTMT能明显降低全血粘度 (ηb)、血浆粘度 (ηp)、纤维蛋白原 (Fib) (P<0 .0 1)及红细胞比容 (HCT) (P<0 .0 5 ) ;缩短红细胞电泳时间 (EET) (P<0 .0 5 ) ,提高红细胞电泳率 (EEM) (P<0 .0 1) ;亦能明显增强红细胞变形性 (DI)(P<0 .0 5 ) ,降低红细胞聚集指数 (AI) (P<0 .0 1) .结论 HXTMT具有改善血液流变性作用 。

AIM To observe effects of Huoxue Tongmai Tablet (HXTMT), a compound preparation made up of pure traditional Chinese medicinal herbs, on hemorheology of acute blood stagnation in rats. METHODS The suspension of HXTMT was given to rats by gastrotube for 1 wk. The rats were given hypodermic injection of 1 g·L -1 adrenaline 0.2 mL twice and a cold stimulation (freezing water at 0℃) for 5 minutes on the 7th day. The model of acute blood stagnation in rats was established and the indexes of hemorheology were detected on the 8th day. RESULTS The tablet significantly reduce η b, η p, Fib ( P <0.01) and HCT ( P < 0.05 ). EET was evidently shortened ( P <0.05), EEM was obviously increased ( P <0.01), DI was clearly strengthened ( P <0.05) and AI was markedly receded ( P <0.01). CONCLUSION HXTMT is effective in improving hemorheology. The results indicate that the tablet can be used to prevent blood hyperviscosity syndrome and ischemic heart disease.