幽门螺杆菌的cagA基因和iceA基因与胃十二指肠疾病的关系

The relationships between the cag A and ice A status of Helicobacter pylori and upper gastrointestinal diseases

目的 :探讨幽门螺杆菌 (Helicobacterpylori,Hp)cagA基因及iceA基因的存在情况与胃十二指肠疾病的关系。方法 :用PCR方法检测 174例临床病人胃粘膜活检标本中Hp的cagA基因及iceA基因的存在情况。 结果 :cagA的检出率为 89.7% (15 6 / 174) ,iceA1的检出率为 6 2 .1% (10 8/ 174) ,iceA2的检出率为 32 .2 % (5 6 / 174) ,7例为iceA1和iceA2皆阳性 ,3例未能检测到iceA等位基因型。各疾病组间cagA、iceA1、iceA2的检出率无统计学差异。结论 :cagA基因及iceA基因不能作为本地区Hp毒力增强的标志。

Objective: To investigate the relationships between the cag A and ice A status of Helicobacter pylori and the upper gastrointestinal diseases. Methods: Gastric biopsy specimens from 174 patients with H. pylori infection were analyzed by polymerase chain reaction. Results: cag A was present in 156 (89.7%) of 174 cases. ice A1 was found in 108(62.1%) and ice A2 in 56 (32.2%) of the 174 cases. 7 were positive for both ice A1 and ice A2, and 3 were negative for both ice A alletes. The prevalence of the cag A, ice A1 and ice A2 in each upper gastrointestinal disease groups had no statistical difference. Conclusion: cag A and ice A are not markers of H. pylori strains that appears more pathogenic.