2(3)-叔丁基-4-羟基茴香醚对大鼠醋酸溃疡的治疗作用

Role of 2(3)tert-butyl-4-hydroxyanisole in the healing of gastric ulcer induced by acetic acid in rats

目的 :观察 2 (3) 叔丁基 4 羟基茴香醚 [2 (3)tert butyl 4 hydroxyanisole ,BHA]对醋酸诱发大鼠胃溃疡的治疗作用。方法 :用 5 0 % (体积分数 )醋酸烧灼胃前壁浆膜面 1min ,制备大鼠胃溃疡模型。动物随机分为 3组 :BHA组、奥美拉唑组和对照组。测定指标包括 :溃疡指数、粘膜再生指数和溃疡底暴露减少指数。结果 :BHA组和奥美拉唑组溃疡指数分别为 (2 .98± 1.33)mm2 和 (2 .71± 1.45 )mm2 ,显著低于对照组 (5 .86± 1.6 9)mm2 (P <0 .0 1)。BHA组和奥美拉唑组溃疡粘膜再生指数分别为 (70 .1± 7.9) %和 (79.0± 8.1) % ,较对照组 (5 4.5± 7.3) %显著增加 (P <0 .0 0 1)。BHA组和奥美拉唑组的溃疡底暴露减少指数分别为 (6 0 .3± 13.4) %和 (6 8.2± 8.4) % ,较对照组 (46 .5± 7.9) %显著增加 ,P值分别小于 0 .0 5和 0 .0 1。但BHA组与奥美拉唑组相比 ,P值均大于 0 .0 5。结论 :BHA能促进醋酸诱发溃疡的愈合 ,其疗效与奥美拉唑相似。

Objective: To investigate therapeatic effects of 2(3)tert butyl 4 hydroxyanisole (BHA) against gastric ulcer induced by acetic acid in rats. Methods: Chronic gastric ulcer was induced by 50/100 (v/v) acetic acid applied to the lower corpus on the anterior wall for one minute in rats. The rats were randomly divided into 3 groups as follows: BHA group, Omeprazole group and control group. Ulcer index (mm), index for mucosal regeneration (%), and index for decrease in exposed ulcer floor (%) were determined. Results: The ulcer indexes of BHA group and Omeprazole group were (2.98±1.33) mm 2 and (2.71±1.45) mm 2 respectively, which were significantly lower than that of the control (5.86±1.69) mm 2 ( P <0.01). The indexes for mucosa regeneration of BHA group and Omeprazole group were (70.1±7.9)% and (79.0±8.1)% respectively, which were significantly higher than that of the control (54.5±7.3)% ( P <0.001). The indexes for decrease in exposed ulcer floor of BHA group and Omeprazole group were (60.3±13.4)% and (68.2±8.4)%, which were significantly higher than that of the control (46.5±7.9)% ( P <0.05 and P <0.01, respectively). No significant difference was observed between BHA group and Omeprazole group ( P >0.05). Conclusion: These results showed that BHA could promote ulcer healing by acetic acid induced gastric ulcer in rats, and was as effective as Omeprazole. (J Beijing Med Univ, 2000,32:125 127)