摘要
采用微管吸吮技术观察了体外培养肺血管内皮细胞及新鲜分离的红细胞在用青心酮处理后生物力学特性的变化。与未用药组比较 ,在加用青心酮 30 m in后 ,中、大剂量组内皮细胞弹性系数 K1 和 K2 增大 (P<0 .0 5 ) ,粘性系数 μ变化不大 ;红细胞表观变形指数和最大变形值也明显增加 (P<0 .0 5或 P<0 .0 1)。提示青心酮可以增加肺血管内皮细胞弹性 ,并使红细胞变形能力明显增强 ,这可能是青心酮改善血液循环的生物力学机制。
The effects of DHAP on biomechanic properties of cultured pulmonary vessel endothelial cells and isolated erythrocytes were studied by using micropipette aspiration methods. Thirty min after addition of DHAP, the elastic coefficient K1 and K2 of endothelial cells were increased in a dose dependent manner ( P <0.05), and the apparent deformation index and the maximum deformation of erythrocytes elevated ( P <0,05 or P <0.01), while the viscositic coefficient changed slightly as compared with control group. The results indicated that DHAP could increase the elasticity of endothelial cells and the the deformability of erythrocytes, which might be responsible for the biomechanical mechanism that DHAP improved the circulation.
出处
《同济医科大学学报》
CSCD
2000年第2期116-118,共3页
Acta Universitatis Medicinae Tongji
基金
国家自然科学基金!(No.39470 72 7)
湖北省卫生厅资助
