糖尿病大鼠尿TNF-α与肾脏超微病理变化的关系

Relationship between the Change of Urinary TNF-α and Renal Ultrastructure in Diabetic Rats

对肿瘤坏死因子 - α(TNF- α)在糖尿病肾病 (DN)发病机理中的作用进行了研究。观察糖尿病 (DM)大鼠用苯那普利治疗组与非治疗组血、尿 TNF-α及尿白蛋白 (AL b) ,β2 -微球蛋白 (β2 - M)及肾脏超微病理变化。结果发现DM大鼠尿 TNF-α增加与尿 AL b、β2 - M含量、肾小球基底膜 (GBM)厚度呈正相关。用苯那普利治疗能改善上述变化。说明 TNF- α参与 DN早期发病 ,苯那普利能抑制尿 TNF- α及尿蛋白排出 ,减轻 GBM改变。

The role of TNF α in the pathogenesis of diabetic nephropathy(DN) was investigated. Urinry ALb,β 2 M,serum and urinary TNF α in the diabetic rats treated with or without benazepril were measured and the changes in renal ultrastructure observed. It was found that the increase of urinary TNF α was positively correlated with the increases of levels of urinary Alb , β 2 M and GMB thickness in the DM rats. The treatment of benazepril could improve the above changes. It was indicated that TNF α might play a role in the pathogenesis of DN. Benazepril could inhibit the excretion of the urinary TNF α and protein and alleviate the GMB change.