TEC方案在局部晚期乳腺癌中的疗效观察

The Observation of Effect of TEC Regimen in the Treatment of Partial Advanced Breast Cancer

目的探讨多西他赛加表阿霉素加环磷酰胺(TEC方案)行新辅助化疗在局部晚期乳腺癌治疗中的疗效观察。方法 38例未经治疗的IIb—IIIc期的局部晚期乳腺癌予TEC方案行新辅助化疗。入组患者化疗前均接受肿瘤原发灶空芯针穿刺活检并取得病理组织学确诊。结果 TEC方案新辅助化疗在局部晚期乳腺癌的治疗中总有效率84.2%,其中临床完全缓解15.8%(6/38),临床部分缓解63.2%(24/38),病理完全缓解5.3%(2/38)。主要的毒副反应为白细胞减少、脱发和恶心、呕吐,无败血症和死亡病例。结论 TEC方案新辅助化疗在局部晚期乳腺癌的治疗中疗效显著,耐受性好。

Objective to evaluate the effect and toxicity reflection of TEC scenario（docetaxel plus epirubicin and cyelophosphamide） in the treat- ment of partial advanced breast cancer （PABC） . Methods 38 patients with grade IIb ~ Ⅲc LABC received chemotherapy with the TEC regimen. Core needle biopsy samples were obtained before the initiation of chemotherapy. Results The overall response rate of TEC scenario in the treatment of LABC was 84. 2%, clinical CR rate is 15.8% in 6 cases, clinical PR rate is 63.2% in 24 cases, and PCR rate is 5.3% in 2 cases. The main commontoxici- ties are leukopenia, alopecia, nausea and vomiting. There was no serious septicemia and toxic deaths. Conclusion Chemotherapy with the TEC regimen is very effective in the treatment of partial advanced breast cancer （PABC）.