颈动脉斑块中脂质比例与心血管危险因素的相关性研究

The relationship between the proportion of lipid in carotid arterial plaque and various cardiovascular risk factors

目的通过量化分析颈动脉斑块成分，探讨斑块中脂质比例与LDL—C等心血管危险因素的相关性。方法采用超声影像量化分析171例疑似颈动脉狭窄及颈动脉硬化患者颈动脉斑块中脂质比例，并与年龄、性别、SBP、DBP、TC、TG、HDL—C、IL-6、MMP-9等心血管危险因素进行相关性分析。结果与无斑块者比较，II型斑块者饮酒、肥胖比例增高（均P〈0.05），I型斑块、II型斑块、III型斑块患者SBP、TC、TG、LDL—C、CRP、IL-6、MMP-9水平均升高（P〈0．05或0．01），血清HDL—C降低（P〈0．05）。颈动脉斑块中脂质比例与IL-6、MMP-9、SBP、TC、TG、LDL—C、CRP呈正相关（均P〈0．05），与HDL—C呈负相关（P〈0.05），且与饮酒、肥胖等心血管危险因素有关（r=0．273、0．261，P〈0．05）。结论颈动脉斑块中脂质比例与LDL—C等心血管危险因素有密切关系，是影响动脉斑块稳定性的重要病理因素，可作为预测临床心血管疾病的危险因子。

Objective To investigate the relationship between the proportion of lipid in carotid arterial plaque and various cardiovascular risk factors. Methods The proportion of lipid in carotid arterial plaque was measured by ultrasound densitometry analysis in 171 patients with suspected carotid atherosclerotic plaques. The correlation of components of plaque with various cardiovascular risk factors, including age, gender, pulse pressure, TC, TG, HDL-C, IL-6, MMP-9 was analyzed. Results The rates of alcohol drinking and obesity in plaque II group were higher than those in non-plaque group （P〈0.05）. Compared with the non-plaque group, the levels of SBP,TC,TG,LDC-C,CRP,IL-6,MMP-9 of plaque I, plaque II and plaque III groups were higher, the levels of HDL-C were lower （P〈0.05 or 0.01）. The proportion of lipid in carotid arterial plaque showed positive correlation with the levels of IL-6, MMP-9, BP, TC, TG, LDL-C, CRP （P〈0.05）, and negative correlation with the levels of HDL-C （P〈 0.05）. Alcohol drinking and obesity were associated with cardiovascular risk （r=0.273,0.261, P〈0.05）. Conclusion The proportion of lipid in carotid arterial plaque is closely related to various cardiovascular risk factors, it is also associated with the stability of plaque.