摘要
目的:建立阿戈美拉汀原料中镍残留量的检测方法。方法:采用火焰原子吸收分光光度法,以吡咯烷二硫代氨基甲酸铵-甲基异丁基酮体系萃取富集制备样品,在232.0 nm波长处测定吸光度,按外标法计算镍含量。结果:镍在0.05～4.00μg·ml-1浓度范围内有良好的线性关系(r=0.999 0),平均回收率为93.3%。结论:该法简便快捷,重复性好,能准确测定阿戈美拉汀原料中镍残留量。
Objective： To develop a method for the determination of nickel in agomelatine.Method： The flame atomic absorption spectrometry was applied to determine the content of nickel in agomelatine enriched by the solvent system of ammonium pyrrolidinedithiocarbamate（APDC）-methyl isobutyl ketone（MIBK）at 232.0 nm.The external standard method was performed to calculate the sample concentration.Result： The linear range of nickel was 0.05-4.00 μg·ml-1（r=0.999 0）.The average recovery was 93.3%.Conclusion： The method is simple,accurate and rapid,and it can be used in the quality control of agomelatine.
出处
《中国药师》
CAS
2012年第10期1414-1415,共2页
China Pharmacist
关键词
火焰原子吸收法
阿戈美拉汀
镍
Flame atomic absorption spectrometry
Agomelatine
Nickel
