COPD所致肺动脉高压与同型半胱氨酸相关性研究

Study on the Correlation between Homocysteine and Pulmonary Hypertension(PH) Induced by Chronic Obstructive Pulmonary Disease

目的:探讨慢性阻塞性肺疾病(COPD)所致不同程度肺动脉高压(PH)与血浆同型半胱氨酸(Hcy)的相关性。方法:应用反相高效液相色谱荧光检测法测定了COPD合并PH轻、中、重度患者以及COPD合并高血压及PH轻、中、重度患者的Hcy,采用SPSS 17.0软件对数据进行统计分析。结果:COPD合并PH轻、中、重度患者血浆Hcy差异无统计学意义(P>0.05),但COPD合并PH及高血压患者的Hcy明显高于未合并高血压患者(P<0.05)。结论:检测血浆Hcy对于高血压疾病的预防、诊断具有重要的临床应用价值,但对于COPD合并PH疾病无太大的临床应用价值。

Objective： To investigate the correlation between plasma homocysteine（Hcy） and pulmonary hypertension（PH） induced by chronic obstructive pulmonary disease（COPD）.Method： Hcy was determined by RP-HPLC in the patients with COPD and PH at the level of light,moderate and severe and the patients with hypertension induced by COPD and PH at the level of light,moderate and severe.The data were analyzed by SPSS 17.0 statistical software.Result： The content of plasma Hcy showed no statistical difference in the patients with COPD and PH（P0.05）,while that in the patients with hypertension induced by COPD and PH was much higher（P0.05）.Conclusion： It is important to detect plasma Hcy in preventing and diagnosing hypertensive diseases,while it is less valuable in the patients with COPD and PH.