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结构修饰对改善药物生物药剂学性质的研究进展 被引量:2

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摘要 据统计,在新药研发过程中,有近40%的药物由于体内药动学性质不适而被淘汰,其原因主要包括:①口服生物利用度低,达不到有效治疗浓度;②体内半衰期短,作用时间短,治疗浓度低;③靶部位浓度低,达不到治疗效果[1]。在新药设计中,很多优秀药物并不是完全新型结构的化合物,
出处 《中国药师》 CAS 2012年第10期1495-1498,共4页 China Pharmacist
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